Nowadays, human life expectancies are increasing, and studies on aging biology are looking to elucidate the biochemical and genetic processes that lead to aging over time and to find new strategies to counter this process. Aging is a process in which there is an irreversible and progressive decline of physiological functions; this loss could lead to the most important age-related diseases, such as cardiovascular diseases, musculoskeletal disorders and arthritis, neurodegenerative diseases, and cancer.Recently, a number of studies have reported that fecal microbes, blood, cerebrospinal fluid and other substances from young individuals can reverse aging in elderly individuals, which may ......2022-12-16

Prostate cancer(PCa)is the most frequent malignancy in the worldwide male population as well as one of the most common among all the leading cancer-related death causes. Although several men receive an early-stage disease diagnosis and run an indolent course, many cases are characterized by locally advanced or metastatic disease, at the time of diagnosis. Considering the worst course of the advanced disease, a hard challenge for clinicians has been to find a therapeutic approach for these patients in order to improve their prognosis as much as possible.Thus, further exploration of the mechanisms underlying PCa may facilitate the development of more effective therapies.1. A COP1-GATA2 a......2022-12-10

On October 24, 2022, Tiebang Kang, Sun Yat-sen University Cancer Center, China, and his team published a paper titled “Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity” in Cell Research. They reported that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical autophagy.The kits [High Sensitive ELISA Kit for Transmembrane Protein 173 (TMEM173), HEN011Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune ......2022-12-07

On 12 October,2022, Linhu Ge, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, China, and his team published a paper titled “SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis” in Journal of Advanced Research. They showed that SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of P. gingivalis.The kits [ELISA Kit for Serum Amyloid P Component (SAP), SE......2022-12-03

On Oct 24, 2022, professor Tiebang Kang from Sun Yat-sen University Cancer Center published a paper titled Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity on Cell Research.STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical autophagy. Mechanistically, RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex, inducing the formation......2022-12-03

The International Association for the Study of Pain (IASP) Task Force recently proposed a new definition of pain as an aversive sensory and emotional experience typically caused by, or resembling that caused by, actual or potential tissue injury. Importantly, acute pain serves a critical Darwinian protective function: to initiate an escape response from noxious stimuli that in the future should be avoided for personal safety. However, chronic intractable pain is maladaptive and constitutes a widespread public health issue, significantly impairing quality of life. Pain may arise from multiple mechanisms, and this complexity reflects the difficulty in achieving significant relief. Recent......2022-11-25