On September 30, 2022,Qiujing Yu, Division of Infectious Disease, Second Hospital of Tianjin Medical University, China, and his team published a paper titled “Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis” in Cellular & Molecular Immunology. Their findings clarify a previously unknown mechanism by which serine metabolism plays a key role in orchestrating macrophage polarization.The kits[ELISA Kit for S-Adenosyl Methionine (SAM), CEG414Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism reg......2022-11-23

Bacteriophages (phages) are viruses that selectively infect bacteria. Phages can be biologically active within bodies, infecting and subsequently killing and lysing bodyassociated bacteria, and the application of phages to bodies to combat bacterial infections is called phage therapy. However, the discovery of antibiotics, subsequent large-scale industrial production, and wide clinical application have caused phage therapy to become unfavorable. In recent years, phage therapy has been re-emphasized as the severity of drug-resistant bacterial infections has increased. Indeed, phages alone or combined with antibiotics have been successfully used to treat diferent bacterial infections, in......2022-11-21

On October 19, 2022,Xin Pan, Nanhu Laboratory, National Center of Biomedical Analysis, China, and his team published a paper titled “Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling” in Cell Stem Cell. Their findings established that glioblastoma stem cells (GSCs)-specific metabolite secretion remodels the tumor microenvironment and highlight histamine targeting as a potential strategy for glioblastoma multiforme (GBM) therapy.The antibodies[Polyclonal Antibodyto Histidine Decarboxylase (HDC), PAG476Hu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The communication betwee......2022-11-17

On October 14, 2022,Cui Hua Liu, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China, and his team published a paper titled “A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin” in Science. Their data reveal a role of the pathogen-derived phospholipid phosphatase in the regulation of GSDMD-dependent pyroptosis and cytokine releases, extending understanding of the elaborate regulatory mechanism of cellular inflammasome-pyroptosis signaling pathways during pathogen infection.The kits [ELISA Kit for Interferon Gamma (IFNg), SEA049Mu] of Cloud-Clone brand was chosed in this article,......2022-11-11

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)characterized by demyelination, axonal damage, and progressive neurologic disability.MS is a disease that affects brain, spinal cord and the optic nerves. The main symptoms include fatigue, tremor, motor dysfunction, nystagmus, numbness, loss of coordination or balance, disturbances in speech and vision, cognitive impairment and acute paralysis, and it is one of the most common neurological (non-traumatic) cause of disability in young adults. The etiology and pathogenesis of MS is complex and remain elusive, although both genetic and environmental factors are involved. Recently, several studies on the p......2022-11-04

On August 28, 2022, Sijin Liu, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, China, and his team published a paper titled “New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis” in Advanced Science. They found that a new compound can suppress iron-induced ferroptosis by modulating the intracellular signaling that drives lipid peroxidation. The kits [ELISA Kit for Beta-2-Microglobulin (b2M), SEA260Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Excess iron accumulation ......2022-11-03