Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF)

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CSF2; GM-CSF; Sargramostim; Molgramostin; Granulocyte-Macrophage Colony Stimulating Factor

Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF)

Granulocyte-macrophage colony stimulating factor (GM-CSF) was initially identified by its ability to stimulate the formation of granulocyte and macrophage colonies from hematopoietic progenitor cells in semi-solid media. In vivoand in vitro studies have now demonstrated that GM-CSF is a pleiotropic cytokine that induces myeloid precursor cells to proliferate and differentiate into neutrophils, monocyte/macrophages and eosinophils.

GM-CSF has also been shown to stimulate the proliferation and differentiation of erythroid and megakaryocyte progenitor cells. In addition, GM-CSF is a survival factor for and activates the effector functions of mature neutrophils, monocytes/macrophages and eosinophils.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA045Hu01 Recombinant Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
EPA045Hu61 Eukaryotic Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA045Hu61 Active Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Cell culture; Activity Assays.
APA045Hu01 Active Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Cell culture; Activity Assays.
Antibodies PAA045Hu01 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
MAA045Hu22 Monoclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
PAA045Hu06 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
Assay Kits SEA045Hu ELISA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA045Hu CLIA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA045Mu01 Recombinant Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA045Mu02 Recombinant Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA045Mu01 Active Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Cell culture; Activity Assays.
Antibodies PAA045Mu01 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
PAA045Mu02 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
Assay Kits SEA045Mu ELISA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA045Mu CLIA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA045Ra01 Recombinant Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA045Ra01 Active Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Cell culture; Activity Assays.
Antibodies PAA045Ra01 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
MAA045Ra21 Monoclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
Assay Kits SEA045Ra ELISA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA045Ra CLIA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA045Ca01 Recombinant Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA045Ca01 Polyclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
MAA045Ca21 Monoclonal Antibody to Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) WB; IHC; ICC; IP.
Assay Kits SEA045Ca ELISA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA045Ca CLIA Kit for Colony Stimulating Factor 2, Granulocyte Macrophage (GMCSF) Chemiluminescent immunoassay for Antigen Detection.
  1. "Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells."Proc. Natl. Acad. Sci. U.S.A. 82:4360-4364(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor."Proc. Natl. Acad. Sci. U.S.A. 83:3101-3105(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor."Proc. Natl. Acad. Sci. U.S.A. 82:6250-6254(1985) [PubMed] [Europe PMC] [Abstract]
  4. "Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins."Science 228:810-815(1985) [PubMed] [Europe PMC] [Abstract]
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  6. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells."Biochemistry 31:1881-1886(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor."Science 254:1779-1782(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor."J. Mol. Biol. 224:1075-1085(1992) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation."Cell 134:496-507(2008) [PubMed] [Europe PMC] [Abstract]