On June 7, 2023,Hailing Qiao, Institute of Clinical Pharmacology, Zhengzhou University, China, and his team published a paper titled “Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti-Tumor Agent” in Advanced Science. They discovered a previously unknown pro-tumorous mechanism in which the CYP2E1-PPARγ-STAT- 1/NF-κB/STAT-3/STAT-6 axis induced glioblastoma (GBM) cell proliferation and inhibited apoptosis to fuel tumorigenesis and tumor growth.The protein [Recombinant Cytochrome P450 2E1 (CYP2E1), RPA988Ra01] of Cloud-Clone brand waschosed in this article, we are so proud for supporting the reaserchers.Glioblastoma (GBM) i......2023-07-21

Cystic fibrosis (CF) is a multisystem autosomal recessive disease that is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein is an ion channel that functions to regulate the transepithelial movement of anions predominantly in mucus-secreting tissues, thereby acting to orchestrate the balancing of salt and fluid levels in mucus secretions. Disease-causing mutations in this gene affect multiple organs in CF including the gut, pancreas, and the liver, but it is the impact of dysregulated CFTR function in the airways that proves particularly harmful to individuals with CF. Dehydration of the airway surface liquid and thickening of m......2023-07-18

On June 20, 2023, Seon-Yong Jeong, Department of Medical Genetics, Ajou University School of Medicine, Korea, and his team published a paper titled “UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis” in Nature Communications. Their research suggested that UBAP2 has a critical role in bone homeostasis through the regulation of bone remodeling.The kits [ELISA Kit for Ubiquitin Associated Protein 2 (UBAP2), SEE593Hu] of Cloud-Clone brand were chosed in this article, we are so proud for supporting the reaserchers.Osteoporosis is a condition characterized by decreased bone mineral density (BMD) and reduced bone strength, leading t......2023-07-13

Anemia, a disease characterized by decreased numbers of circulating red blood cells and/or hemoglobin, is a major public health problem worldwide, with a prevalence greater than 30%. Recently, this disease has become more prominent due to an aging population and a higher incidence of chronic diseases and cancers. In humans, anemia can be caused by different pathophysiologic processes; for example, primary anemia is caused by hematopoietic system abnormalities, while secondary anemia is induced by chronic diseases, kidney diseases, and cancers, among others. As the most common hematological manifestation, anemia can affect recovery from the disease itself.Therefore, systematic and in-de......2023-07-10

On June 6, 2023,Bin Ding, Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, China, and his team published a paper titled “Flexible Bioactive Glass Nanofiber-Based SelfExpanding Cryogels with Superelasticity and Bioadhesion Enabling Hemostasis and Wound Healing” in ACS Nano. They developed a self-expanding nanofibrous cryogel composed of highly flexible BG nanofibers and citric acidcross-linked poly(vinyl alcohol) (PVA) with superelasticity, bioadhesion, and bioactivity.The kits[ELISA Kit for Brain Natriuretic Peptide (BNP), CEA541Ra] of Cloud-Clone brand were chosed in this article, we are so proud for supporting the reaserchers.Self-exp......2023-07-07

On May 9, 2023,Li-Chung Hsu, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taiwan, and his team published a paper titled “The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage” in Journal of Experimental Medicine. Their study highlights the c-Src–ZNRF1 axis as a negative feedback mechanism controlling TLR3 trafficking and the termination of TLR3 signaling.The kits[ELISA Kit for Interferon Beta (IFNb), SEA222Mu] of Cloud-Clone brand were chosed in this article, we are so proud for supporting the reaserchers.Type I interferons are important antiviral cytokines, but prolonged interferon production is de......2023-07-03