TGFb1 - An angel or a devil?Recently, researchers found thatTransforming Growth Factor beta 1(TGFb1) has two sidesin tumor.It is a tumor suppressor through decreasingthe proliferation of cancer cells, but in the mean while, it is also a tumor promoter by promoting formation of tumor micro-environment which benefits the growth, infiltration and transfer of tumor cells.Next, we will make a brief introduction of the regulating function of TGFb1 in tumor, its clinical value and quantification method.TGFb1 belongs to TGFb subfamily, this family also includes TGFb2, TGFb3, TGFb4, et al. Proteins in TGFb subfamily are multifunctional, they regulate cell growth and differentiation in body. ......2018-12-26

Keywords: PINP; Bone metabolism; Tumor; Clinical diagnosisWith the increasingof elderly populationin the world, bone metabolism related diseases have become one of the top ten common diseases. Therefore, bone metabolism is a hotspot in medical researches.More and more researchers and clinicians began to look for clinical diagnostic markers of bone metabolism related diseases.Currently, a large number of studies have shown that PINP (Procollagen I N - Terminal Propeptide), a bone formation marker, is closely related to a variety of bone metabolic diseases, tumor bone metastasis and multiple myeloma.And its detection is not affected by food, circadian rhythm, hormones and other interfere......2018-12-11

Neurodegenerative diseases are associated with the loss of neurons and/or the myelin sheaths. The disease worsens as time goes on, and leading to dysfunction. Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and Amyotrophic Lateral Sclerosis (ALS) are the most common neurodegeneration diseases.For a long time, people thought that once nerve cells in the brains of adult mammals are damaged, they are unable to regenerate. This thought led to the major limitation in the treatment of neurodegenerative diseases. The principle of current treatment is to improve symptoms and slow the progression of the disease. In recent years, great progress has been ......2018-10-22

1. Baking:Bake the IHC slides for 0.5~2 hours at60℃.2. Deparaffinization and rehydration: After thebaking, put slides into the following reagents in order:1)XyleneI: 30 minutes2)XyleneII: 30 minutes3)100%ethanol: 10 minutes4)95%ethanol: 10 minutes5)80%ethanol: 10 minutes6)70%ethanol: 10 minutes7)Rinse sections with running water 10 minutes3. Antigen retrieval - Microwave heat antigenretrieval (optional): Transfer the slides into a boiling EDTA-TRIS solution,and ensure the slides are soaked completely. Low fire for one minute, stopheating and keep in microwave for 10min, then another low fire for 3-4 min, andallow slides to cool in the EDTA-TRIS solution at room temperature.4.Rinse 3X......2018-04-23

From the discovery of the structure of DNA makes people have a preliminary understanding of gene structure, to the emergence of PCR technology to achieve gene amplification in vitro, and then to the PCR based gene sequencing technology. The first time we have seen the whole information of human genome library. But no matter how the genetic manipulation technique develops, it can not change people's fanatical pursuit of gene editing technology, and that because it’s directly related to human diseases of diagnosis and treatment, bear and rear better children and the evolution of race. Gene editing technology has gone through 3 stages of development. The first and second generation ......2017-07-07

Primary liver cancer is one of the most common malignant tumors, according to statistics, the annual mortality of liver cancer is second highest of all cancers’ mortality, morbidity and mortality of liver cancer in China is the largest in the world, accounting for 55% of the new incidence and deaths each year. And the number of liver cancer patients is increasing year by year. Because of its high malignant degree, aggressiveness, rapid growth, easy recurrence, metastasis and other biological characteristics, it is known as the 'king of cancer'. Despite the current various surgical, chemotherapy and other treatment methods continue to improve, the effect is still poor. In rece......2017-07-07