Anti-Mullerian Hormone(AMH), also known as Mullerian Inhibiting Substance(MIS), belongs to Transforming Growth Factor-β(TGF-β)superfamily. Mature AMH binds two identical 72 KD monomers by disulfide bond to form a dimer glycoprotein, which plays abiological role in binding with AMH receptor II (AMHR II). In assessing ovarian reserve, AMH was earlier than FSH, Estradiol (E2),InhibinB (InhB) and Antral Follicle Count (AFC) in reflecting the decline of ovarian reserve with age, and its level was not affected bymenstrual cycle, hormonal contraceptives and pregnancy. Therefore, AMH is one of the most stable, reliable and convenientindicators of ovarian reserve function, and it is one of th......2019-08-16

High Mobility Group Protein 1 (HMGB1) is a highly conserved nuclear protein widely distributed in mammalian cells. With thediscovery of its late pro-inflammatory effect, HMGB1 has become one of the critical medical research spotlights in recent years.HMGB1 consists of three functional regions: two DNA-binding regions (A and B Boxes) and one connected with the negativelycharged C-terminus. The HMGB1 B-box is involved in the release of cytokines and is a functional domain that causes inflammatoryresponses, promots the release of cytokines; the A-box does not induce the cytokine production, whereas the recombinant A-boxcompetes with HMGB1 for binding sites, alleviaties the HMGB1-caused ca......2019-08-06

Procollagen III N-Terminal Propeptide (PIIINP) is an amino-terminal peptide produced by cleavage of Aminoterminus peptidasebefore liver cell to extracellular deposition. During this process, PIIINP and type III collagen present the same molecular mass andenter the blood circulation. Therefore, it can be used as an indicator to detect the synthesis of type III collagen. During thedevelopment of cirrhosis, the level of PIIINP(50KD) in serum will increase, and it has a significant positive correlation with the degreeof liver fibrosis. Clinical study found that the level of PIIINP is also associated with liver inflammation and cancer to some extent,especially in patients with primary and m......2019-08-06

Skeletal type I collagen is the most abundant form of collagen in the human body, accounting for about 90% ofbone mass. Type I collagen is mainly synthesized in bone tissue. The first synthesis is procollagen. There is anextended peptide at the N-terminal and C-terminal of the type I procollagen, which is called type I procollagenN-terminal propeptide (PINP). And type I procollagen C-terminal propeptide (PICP); when type I procollagen issecreted outside the cell by osteoblasts, the N-terminal and C-terminal prolonged peptides are cleaved byproteases, except for a small amount deposited in the bone matrix, a large number will enter the blood circulationand eventually be cleared by the l......2019-08-05

Brain Natriuretic Peptide (BNP), also known as B-type Natriuretic Peptide, which is mainly synthesized and secreted by ventricularmyocytes. The main factors to stimulate BNP secretion are the changes in ventricular load and wall tension. It plays a significant rolein regulating the homeostasis of blood pressure and blood volume, diuresis and so on. BNP is species-specific. Rat BNP iscomposed of 45 amino acids, while pig, dog, and human BNP are composed of 32 amino acids. The gene fragment of human BNP islocated at the distal end of the short arm of chromosome 1 and is linked to the upstream ANP fragment. its reverse transcriptionaldeoxyribonucleic acid (cDNA) consists of 1900 nucleotid......2019-08-02

In July 2019, Literature of Cloud Clone products has exceeded 240. Cloud-Clone could provide multipleproteins, antibodies and ELISA kit, which has been praised by customers. （For more information, please visit: www.cloud-clone.com/www.uscnk.cn）2019-08-01