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Recombinant Procollagen I N-Terminal Propeptide (PINP)

P1NP; N-Propeptide Of Type I Procollagen; Procollagen I Amino Terminal Propeptide

  • Product No.RPA957Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Predicted Molecular Mass27.9kDa
  • Accurate Molecular Mass40kDa(Analysis of differences refer to the manual)
  • Residues & TagsGln23~Pro161 with Two N-terminal Tags, His-tag and SUMO-tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 90%
  • Isoelectric Point4.2
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 200  US$ 500  US$ 1000  US$ 3000  US$ 7500 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Trials Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial. Trials: 1745-6215
Clinical Biochemistry Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum ScienceDirect: S0009912012001543
Therapeutic Apheresis and Dialysis Low molecular weight iron dextran increases fibroblast growth factor-23 concentration, together with parathyroid hormone decrease in hemodialyzed patients PubMed: 22458393
International Journal of Clinical & Experimental Pathology IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT) PubMed: PMC3726963
Osteoporosis International PINP as a biological response marker during teriparatide treatment for osteoporosis Pubmed: 24599274
Clinical Cancer Research Zoledronic acid has differential anti-tumour activity in the pre-and post-menopausal bone microenvironment in vivo Aacrjournals: Source
Endocrinology Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat Gain Endocrine: Source
general endocrinology Oxytocin reverse ovariectomy-induced Osteoper and body fat gain Pubmed:24506069
J Neurol Sci. The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism. Pubmed:24629477
Bone. Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models Pubmed:24947449
Journal of Materials Science: Materials in Medicine Phosphatidylethanolamine biomimetic coating increases mesenchymal stem cell osteoblastogenesis Pubmed:24980874
Springerplus. Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases Pubmed:25332877
Pharmacology Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy PubMed: 25871861
frontiers in endocrinology Oxytocin reverses osteoporosis in a sex-dependent manner PubMed: 26042090
MERIT RESEARCH JOURNALS Changes in Bone Metabolism Months after Laparoscopic Morbidly Obese Pre-menopausal Women Mms: Content
Heart Rhythm.  Prognostic value of collagen turnover biomarkers in cardiac resynchronization therapy: A subanalysis of the TRUST CRT randomized trial population Pubmed:26776557
BMJ Open Sport Exerc Med Procollagen markers in microdialysate can predict patient outcome after Achilles tendon rupture content:2
Bibliothekssystem Universität Hamburg Bilaterale Kommunikation zwischen Osteoblasten und Osteoklasten volltexte:2016
Inflammation Research Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy pubmed:27516211
Endocrine Bone turnover response is linked to both acute and established metabolic changes in ultra-marathon runners pubmed:27422791
Heart & Vessels Left ventricular reverse remodeling is not related to biopsy-detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR pubmed:28004175
journal of science and medicine in sport The effect of calcium and vitamin D supplementation on bone health of male Jockeys. pubmed:27568072
Combined aerobic and resistance training improves bone health of female cancer survivors S2352187216300389
Cellular Physiology and Biochemistry Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathy pubmed:27889753
Epilepsy Research The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar rats pubmed:27838501
Sci Rep.  Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice. pubmed:28303909
Metabolism.  Low periostin levels in adult patients with Langerhans cell histiocytosis are independently associated with the disease activity. pubmed:28521873
Heart and vessels Erratum to: Effects on bone metabolism markers and arterial stiffness by switching to rivaroxaban from warfarin in patients with atrial fibrillation pubmed:28314975
SCIENCE & TECHNOLOGY A Study Protocol: Spinal Morphology, Physical Performance, Quality of Life and Biochemical Markers in Adults at Risk of Osteoporotic Fractures 59f7c85aaca272607e2d8d7a
Knee Surg Sports Traumatol Arthrosc Achilles tendon rupture healing is enhanced by intermittent pneumatic compression upregulating collagen type I synthesis pubmed:28668970
Method for the treatment of cardiovascular fibrosis patents:US9594083
Clinical Cases in Mineral and Bone Metabolism Periostin and sclerostin levels in juvenile Paget's disease pubmed:29263750
Journal of Clinical Research in Pediatric Endocrinology Congenital Hypothyroidism and Bone Remodeling Cycle pubmed:27840329
Biomarkers Medicial Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus pubmed:28685602
Heart and Vessels Left ventricular reverse remodeling is not related to biopsy‑detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR 10.1007/s00380-016-0930-y
BioMed Research International Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Research pubmed:29119115
Cytokine 12-month patterns of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor are similar in new-onset and chronic dilated cardiomyopathy in patients both with and without cardiac fibrosis. pubmed:28460256
Advanced Healthcare Materials Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events. pubmed:29120858
Bone. The key role of proinflammatory cytokines, matrix proteins, RANKL/OPG and Wnt/β-catenin in bone healing of hip arthroplasty patients pubmed:29129760
Cell Death And Differentiation TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42 Pubmed:29358671
Nutrients Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study Pubmed:29337906
Osteoporosis International Two-year cortical and trabecular bone loss in CKD-5D: biochemical and clinical predictors Pubmed:28993865
Journal of Nutrition Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency Pubmed:29897564
European Journal of Pharmacology The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism Pubmed:29428468
Journal of Clinical Densitometry Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX study Pubmed:30076009
Hernia Circulating matrix metalloproteinases and procollagen propeptides in inguinal hernia Pubmed:29484522
Pharmacology Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats Pubmed:29898457
Nature Coupling of bone resorption and formation by RANKL reverse signalling Pubmed: 30185903
European Journal of Medical Research Biomechanical and histological analyses of the fracture healing process after direct or prolonged reduction Pubmed: 30180907
Sensors Membrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related Biomarkers Pubmed: 30181433
Trials Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) … Pubmed: 30567604
International Journal of Cancer Effect of induction therapy with lenalidomide, doxorubicin, and dexamethasone on bone remodeling and angiogenesis in newly diagnosed multiple myeloma Pubmed: 30650184
Bone Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis Pubmed: 30610968
Revista de Chimie -Bucharest- Quantification of N-Terminal Procollagen I Propeptide in Patients With Occlusal Trauma Induced by Prosthetic Factors
PLOS ONE Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in mice Pubmed: 30870491
Scientific Reports Low fibrosis biomarker levels predict cardiac resynchronization therapy response Pubmed: 30988339
Current Developments in Nutrition Changes in Calciotropic Hormones and Bone Markers During Pregnancy in Response to a Nutrition+ Exercise Intervention in the Be Healthy in Pregnancy RCT (P11 … Pubmed: 31224444
Stem Cell Research & Therapy Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB … Pubmed: 31324207
Bone The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice Pubmed: 31622775
International Journal of Basic and Clinical Endocrinology Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia Pubmed: 30143940
Bone Mice lacking plastin-3 display a specific defect of cortical bone acquisition Pubmed: 31678489
International journal of molecular sciences Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients Pubmed: 31717649
Journal of Bone and Mineral Research BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling Pubmed: 31914211
ESC Heart Failure Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers Pubmed: 32064780
International Journal of Medical Sciences Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients Pubmed: 31839746
JOURNAL OF BONE AND MINERAL RESEARCH Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation Pubmed: 33180356
JOURNAL OF THROMBOSIS AND THROMBOLYSIS Extracellular matrix collagen biomarkers levels in patients with chronic thromboembolic pulmonary hypertension Pubmed: 33175289
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Development of a novel polysaccharide-based iron oxide nanoparticle to prevent iron accumulation-related osteoporosis by scavenging reactive oxygen … Pubmed: 33049237
journal of bone and mineral research Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone‐specific phenotype Pubmed: 32369212
Endokrynologia Polska FGF23 and primary hyperparathyroidism: is there a link? Pubmed: 32598019
Journal of Orthopaedic Translation Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomized rats
Research square 4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice
淫羊藿水提物及提取药渣的抗骨质疏松药效比较研究
Pamukkale Tıp Dergisi Postmenapozal Tip-2 diyabetes mellitus' lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri'nin değerlendirilmesi
International Journal of Pharmaceutical and Clinical Research Bone Turnover Markers in Osteogenesis Imperfecta and Effect of Bisphosphonate Treatment: First Egyptian Study
Science Advances A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair 33310848
Rheumatology Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis 33221885
Nutrients Low Energy Availability with and without a High-Protein Diet Suppresses Bone Formation and Increases Bone Resorption in Men: A Randomized Controlled Pilot ¡­ 33671093
J Bone Miner Res Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/¦Â©\catenin pathway 33950533
Phytomedicine Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline … 34352588
Nutrients The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized … 34684621
PLoS One Osteoblast-specific inactivation of p53 results in locally increased bone formation 34793446
Bone Res The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV 34759273
Nutrients The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized … 34578973
Chronobiol Int Night shift work and osteoporosis-bone turnover markers among female blue-collar workers in Poland Pubmed:35139709
Cancers (Basel) Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells Pubmed:35158823
Cell Death Discov BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis Pubmed:35523787
Experimental and Molecular Medicine Foxf2 represses bone formation via Wnt2b/β-catenin signaling Pubmed:35668101
Bioactive Materials Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles Pubmed:35386445
Journal of Orthopaedic Translation Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway Pubmed:35228997
Bioactive Materials Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote … Pubmed:35585377
Journal of Orthopaedic Translation Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPA957Hu02 Recombinant Procollagen I N-Terminal Propeptide (PINP) Positive Control; Immunogen; SDS-PAGE; WB.
APA957Hu61 Active Procollagen I N-Terminal Propeptide (PINP) Cell culture; Activity Assays.
RPA957Hu01 Recombinant Procollagen I N-Terminal Propeptide (PINP) Positive Control; Immunogen; SDS-PAGE; WB.
EPA957Hu61 Eukaryotic Procollagen I N-Terminal Propeptide (PINP) Positive Control; Immunogen; SDS-PAGE; WB.
SPA957Hu02 Synthetic Procollagen I N-Terminal Propeptide (PINP) Immunogen; Blocking Peptide.
CPA957Hu12 BSA Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
CPA957Hu32 KLH Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
CPA957Hu31 KLH Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
CPA957Hu22 OVA Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
CPA957Hu23 OVA Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
CPA957Hu21 OVA Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
SPA957Hu01 Synthetic Procollagen I N-Terminal Propeptide (PINP) Immunogen; Blocking Peptide.
CPA957Hu11 BSA Conjugated Procollagen I N-Terminal Propeptide (PINP) Immunogen; SDS-PAGE; WB.
PAA957Hu08 Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
PAA957Hu09 Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
PAA957Hu01 Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
PAA957Hu02 Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
LAA957Hu81 FITC-Linked Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IF.
LAA957Hu71 Biotin-Linked Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC.
MAA957Hu22 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB
RAA957Hu23 Recombinant Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IF; ICC; IHC; IP; FCM.
RAA957Hu22 Recombinant Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IF; ICC; IHC; IP; FCM.
MAA957Hu24 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
MAA957Hu21 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB,IHC
MAA957Hu28 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC
MAA957Hu23 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
MAA957Hu25 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
MAA957Hu27 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
MAA957Hu29 Monoclonal Antibody to Procollagen I N-Terminal Propeptide (PINP) WB; IHC; ICC; IP.
SEA957Hu ELISA Kit for Procollagen I N-Terminal Propeptide (PINP) Enzyme-linked immunosorbent assay for Antigen Detection.
IEA957Hu Instant ELISA Kit for Procollagen I N-Terminal Propeptide (PINP) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA957Hu ELISA Kit for Procollagen I N-Terminal Propeptide (PINP) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA957Hu Multiplex Assay Kit for Procollagen I N-Terminal Propeptide (PINP) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.
PSA957Hu01 Antibody Pair for Procollagen I N-Terminal Propeptide (PINP) ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
KSA957Hu11 ELISA Kit DIY Materials for Procollagen I N-Terminal Propeptide (PINP) Main materials for "Do It (ELISA Kit) Yourself".
KSA957Hu01 ELISA Kit DIY Materials for Procollagen I N-Terminal Propeptide (PINP) Main materials for "Do It(ELISA Kit) Yourself"