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Polyclonal Antibody to Interferon Beta (IFNb)

IFNB1; IFN-B; IFB; IFF; IFNB; Interferon Beta 1 Fibroblast

SPECIFITY

The antibody is a cavia polyclonal antibody raised against IFNb. It has been selected for its ability to recognize IFNb in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

GIVEAWAYS

INCREMENT SERVICES

Magazine Citations
20 Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway PubMed: 21355876
Journal of General Virology Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKε and DDX3. Sgm: 9182080
Biochemical and Biophysical Research Communications Impaired TLR3/IFN-β signaling in monocyte-derived dendritic cells from patients with acute-on-chronic hepatitis B liver failure: Relevance to the severity of liver damage ScienceDirect: S0006291X09019822
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Vet Microbiol. An attenuated EIAV strain and its molecular clone strain differentially induce the expression of Toll-like receptors and type-I interferons in equine monocyte-derived macrophages. Pubmed: 23850441
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Virus PKR activation enhances replication of classical swine fever virus in PK-15 cells PubMed: 25899421
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Scientific Reports Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4 Pubmed:27090571
Front Microbiol Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo Pubmed:27252695
Canadian Journal of Physiology and Pharmacology Chloroquine attenuates lipopolysaccharide-induced inflammatory responses through upregulation of USP25. pubmed:28134560
International Journal of Molecular Medicine Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function pubmed:27176664
International Journal of Clinical and Experimental Pathology Host miR-146a promotes replication of human cytomegalovirus by suppressing type I IFN response in MRC-5 cells files:ijcep0036479.pdf
Poultry Science ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages pubmed:27486255
Journal of Virology Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized inPlasma and Milk in Chronically Infected African Green Monkeys. pubmed:
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EMBO Journal Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis Pubmed:30065070
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Archives of Virology MAVS induces a host cell defense to inhibit CSFV infection Pubmed:29556776
Journal of virology Inhibition of DNA-sensing pathway by Marek's disease virus VP23 protein through suppression of interferon regulatory factor 7 activation Pubmed: 30518647
Veterinary Immunology and Immunopathology Molecular cloning and functional characterization of porcine 2′, 5′-oligoadenylate synthetase 1b and its effect on infection with porcine reproductive and respiratory?… Doi: 10.1016/j.vetimm.2019.01.003
Science Signaling HIPK2 is necessary for type I interferon–mediated antiviral immunity Doi: 10.1126/scisignal.aau4604
INTERNATIONAL MEDICAL RESEARCH Evaluation of serum interferons in patients with age-related macular degeneration Pubmed: 31007694
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The Journal of Latvian Academy of Sciences Serodiagnosis of Human Bocavirus 1 Infection among Hospitalised Children with Lower Respiratory Tract Infection in Latvia
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FASEB Journal Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF 3 ubiquitination through recruiting OTUB 1
PLOS Pathogens Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion Pubmed: 31539404
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