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Monoclonal Antibody to Interleukin 1 Beta (IL1b)

IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin

SPECIFITY

The antibody is a mouse monoclonal antibody raised against IL1b. It has been selected for its ability to recognize IL1b in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Food & Function Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264. 7 macrophages through the MAPK and NF-κB … DOI:10.1039/C6FO01873D
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Evidence-Based Complementary and Alternative Medicine BuShenKangShuai tablet reduces atherosclerotic lesion by improving blood lipids metabolism and inhibiting inflammatory response via TLR4 and NF-κB signaling pathway journals:1758383
Frontiers in Neurology a-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-觀B Activation and Reduction in Microglia Neuroinflammation. pubmed:29312110
中国免疫学杂志 b-caryophyllene mitigates cerebral ischemia reperfusion injury in mice by inhibiting HMGB1/ TLR4/ NFkB pathway doi:10. 3969 / j. issn. 1000-484X. 2017. 07. 011
Chinese Journal of comparative medicine (中国比较医学杂志) 富氢液通过P13K通路减轻大鼠脑缺血再灌注损伤 doi:10u3969.j.issn.1671-7856
PLoS One Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders 10.1371:journal.pone.0172181
Experimentelle periimplantäre Mukositis an unterschiedlichen Implantatoberflächen doi: 10.1111/jcpe.12240.
International Journal of Biological Macromolecules Chemical composition of Cyclocarya paliurus polysaccharide and inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophage pubmed:29032210
Journal of Photochemistry and Photobiology B: Biology Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prospective randomized split-mouth clinical study 10.1016/j.jphotobiol.2017.03.001
Frontiers in Neuroscience Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro PMC5662640
International Journal of Clinical and Experimental Pathology Platelet-derived growth factor and stromal cell-derived factor-1 promote the skin wound repairing effect of bone mesenchymal stem cells: a key role of matrix metalloproteinase 1 and collagens ISSN:1936-2625/IJCEP0058424
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis pubmed:29207044
Cellular Physiology and Biochemistry Dexmedetomidine Alleviates HyperoxiaInduced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation pubmed:28873369
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Frontiers in Molecular Neuroscience Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats 10.3389/fnmol.2017.00363
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Oncotarget Neuroprotection of Botch in experimental intracerebral hemorrhage in rats. pubmed:29221132
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Autonomic Neuroscience Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease. pubmed:29305058
Endocrine, Metabolic & Immune Disorders-Drug Targets Changes in Serum Nampt Levels and Its Significances in Diabetic Nephropathy Patients-The Potential Role of Nampt in T2DM with Diabetic Nephropathy. pubmed:28699485
Biological Rhythm Research A study of altered cytokine rhythms associated with successful implantation in cows 10.1080/09291016.2017.1361159
Biomedical and Environmental Sciences Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice. pubmed:28756814
Acta Pharmacologica Sinica Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ. pubmed:28649126
International journal of molecular medicine Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma pubmed:29207019
Molecular Medicine Reports Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway pubmed:28944825
Veterinary microbiology Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. pubmed:28532803
Biomedicine & pharmacotherapy Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms pubmed:28061403
International immunopharmacology Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines pubmed:29272819
International immunopharmacology Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro pubmed:28605710
Journal of Neuroinflammation Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage. pubmed:28732502
Journal of Ethnopharmacology Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-κB and JAK2-STAT3 signaling pathways. pubmed:28629818
Journal of Animal Science and Biotechnology Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin. pubmed:29026538
Translational Stroke Research Early Inflammatory Response in the Brain and Anesthesia Recovery Time Evaluation After Experimental Subarachnoid Hemorrhage Pubmed:29926382
Journal of Controlled Release Nose-to-brain delivery of insulin enhanced by a nanogel carrier Pubmed:29196041
PLOS Pathogens Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis Pubmed:29360865
Cell Death & Disease AMP-activated protein kinase agonist N 6-(3-hydroxyphenyl) adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis Articles:s41419-017-0118-0
Journal of Neuroinflammation Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes Pubmed:29357878
Molecular Neurobiology Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects s12035-017-0855-1
Neuropharmacology Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway Pubmed:29518397
Journal of Translational Medicine Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation? Pubmed:29665864
Scientific Reports Mesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy Pubmed:29434214
American Journal of Physiology-Lung Cellular and Molecular Physiology Maternal PUFA omega-3 supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring Pubmed:29597832
Food and Chemical Toxicology Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of Malaysian propolis and metformin in streptozotocin–induced diabetic rats Pubmed:30026088
International Journal of Biological Macromolecules Alcohol accumulation promotes esophagitis via pyroptosis activation Pubmed:30123073
Annals of Intensive Care Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome Pubmed:29721820
British journal of nutrition Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2-dimethylhydrazine-induced rat colorectal … Pubmed:29947321
Frontiers in Neurology Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB … Pubmed:29867706
Journal of Functional Foods Hepatoprotective effect of flavonoid-enriched fraction from Cyclocarya paliurus leaves on LPS/D-GalN-induced acute liver failure 10.1016:j.jff.2018.07.031
Inflammopharmacology Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB Pubmed:29943151
Food & Function Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-κB signaling pathway Pubmed:29354820
Life Sciences Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation Pubmed:29499280
Life Sciences Modified porcine surfactant enriched by recombinant human superoxide dismutase for experimental meconium aspiration syndrome Pubmed:29684443
Life Sciences Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways Pubmed:29679702
Brain Research Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway Pubmed:29510144
Molecular Reproduction and Development  A proinflammatory response of bovine endometrial epithelial cells to active sperm in vitro Pubmed:29337420
International Endodontic Journal Inhibition of SOX9 Promotes Inflammatory and Immune Responses of Dental Pulp Pubmed:29571909
International Journal of Molecular Medicine MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing … Pubmed:29512778
International Journal of Molecular Medicine Interleukin-1β induces intercellular adhesion molecule-1 expression, thus enhancing the adhesion between mesenchymal stem cells and endothelial progenitor cells … Pubmed:29393395
Neurochemical Research E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury Pubmed:29934689
PLoS One Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway Pubmed:29415054
Ultrasound in Medicine & Biology Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis Pubmed:29703511
BMC Infectious Diseases Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols Pubmed:29490620
Journal of Molecular Neuroscience A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes Pubmed:30062438
Experimental biology and medicine (Maywood) Shock waves increase pulmonary vascular leakage, inflammation, oxidative stress, and apoptosis in a mouse model Pubmed:29984607
Innate Immunity  Lipoxin A attenuates LPS-induced acute lung injury via activation of the ACE2-Ang-(1-7)-Mas axis Pubmed:29969931
Clinical And Experimental Pharmacology And Physiology  Diallyl sulfide alleviates cisplatin‐induced nephrotoxicity in rats via suppressing NF‐κB downstream inflammatory proteins and p53/Puma signalling pathway Pubmed:29266336
Evidence-based Complementary and Alternative Medicine Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling … Pubmed:29619063
Evidence-Based Complementary and Alternative Medicine Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus Pubmed:30108663
BMC Veterinary Research Inflammatory pattern of the infrapatellar fat pad in dogs with canine cruciate ligament disease Pubmed:29769086
Molecular Medicine Reports Protective effects of N (2)‑L‑alanyl‑L‑glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion Pubmed:29393473
Molecular Medicine Reports  Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats Pubmed:29956781
Molecular Medicine Reports Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway Pubmed:29620209
Medical Science Monitor Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4) … Pubmed:29804125
Medical Science Monitor Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats Pubmed:29290631
Medical Science Monitor Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit … Pubmed:29527002
Experimental Lung Research Anti-IL-8 antibody potentiates the effect of exogenous surfactant in respiratory failure caused by meconium aspiration Pubmed:29324051
Human and Experimental Toxicology Neuroprotective effect of agmatine (decarboxylated -arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson's disease Pubmed:30001633
Oncology Letters Hydrogen‑rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus‑activated kinase 2/signal transducer and activator of … Pubmed:29928398
Journal of Maternal-Fetal & Neonatal Medicine Amniotic fluid HIF1α and exosomal HIF1α in cervical insufficiency patients with physical examination-indicated cerclage Pubmed:29357727
Experimental and Therapeutic Medicine S‑adenosyl methionine regulates calcium channels and inhibits uterine smooth muscle contraction in rats with infectious premature delivery through the transient … Pubmed:29896230
Animal Production Science Omega-3 fatty acids and meloxicam supplementation and the incidence and histopathological changes associated with femoral head syndrome in broilers 10.1071:AN17713
International Journal of Clinical and Experimental Medicine BoNT-A attenuated pain of endometriosis by inhibiting microglia activation files:ijcem0055240.pdf
International Journal of Pharmacology Evaluation of Susceptibility and Innate Immune Response to Candida albicans in Mice with Sub-health ijp.2018.689.697
Journal of Diabetes Investigation Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance Pubmed:29432659
Life Sciences Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats Pubmed: 30205096
International Journal of Clinical and Experimental Medicine The relationship between autophagy and apoptosis of lamina propria dendritic cells from the small intestine on the immunodynamics of sepsis mice
European Journal of Pharmacology Inhibition of Rho kinase by GSK 269962 reverses both corticosterone-induced detrusor overactivity and depression-like behaviour in rats Pubmed: 30172788
Acta Medica Mediterranea Effects of Conventional Mechanical Ventilation Performed by Two Neonatal Ventilators on the Lung Functions of Rabbits with Meconium-Induced Acute Lung … Doi: 10.1515/acm-2016-0012
IUBMB Life SLC1A2 mediates refractory temporal lobe epilepsy with an initial precipitating injury by targeting the glutamatergic synapse pathway Pubmed: 30360015
Neurobiology of Disease Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain Pubmed: 30347266
Journal of Dairy Science Metabolism and immune status during transition period influences the lactation performance in Zebu (Bos indicus () cows Pubmed: 17430930
Microbial Pathogenesis Total flavones of fermentation broth by co-culture of Coprinus comatus and Morchella esculenta induces an anti-inflammatory effect on LPS-stimulated RAW264. 7 … Pubmed: 30316005
Experimental Cell Research LL-37 inhibits LPS-induced inflammation and stimulates the osteogenic differentiation of BMSCs via P2X7 receptor and MAPK signaling pathway Pubmed: 30287143
Prostaglandins & Other Lipid Mediators Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury Pubmed: 30453089
Biomedicine & Pharmacotherapy Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro
International Journal of Molecular Sciences Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental … Pubmed: 30463256
Oxidative medicine and cellular longevity Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE−/− Mice
Toxicology Mechanisms and Methods Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats Pubmed: 30426860
BioMed Research International α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress
PLoS One Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury Pubmed: 30571701
BBA- Molecular Basis of Disease Enhanced remedial effects for vitamin D3 and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic … Pubmed: 30553018
Archives of Physiology and Biochemistry Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin Pubmed: 30513216
International Journal of Molecular Medicine Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro Pubmed: 30535505
Journal of Veterinary Research Early cytokine response after vaccination with Coxiella burnetii phase I in an infected herd of dairy cattle
Neurochemical Research Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway Pubmed: 30603983
EXPERIMENTAL ANIMALS Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation Pubmed: 30606939
ACS Applied Materials & Interfaces Rebuilding post-infarcted cardiac functions by injecting TIIA@ PDA NPs-crosslinked ROS sensitive hydrogels Pubmed: 30592403
Chinese Journal of Integrative Medicine Electroacupuncture Delays Cartilage Degeneration by Modulating Nuclear Factor-κB Signaling Pathway Pubmed: 30656598
Kidney International Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome Pubmed: 30770217
Inflammation Honokiol Attenuates Sepsis-Associated Acute Kidney Injury the Inhibition of Oxidative Stress and Inflammation Pubmed: 30680694
Toxicology Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: a role in Kupffer cell activation Pubmed: 30685357
Acta Biochimica et Biophysica Sinica Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway Pubmed: 30668810
Journal of Neuroinflammation Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease Pubmed: 30777084
Phytotherapy Research Synergistic enhancement and hepatoprotective effect of combination of total phenolic extracts of L. and methotrexate for treatment of rheumatoid?… Pubmed: 30729592
Journal of Biological Sciences Maged Mohamed Abd-Elhakim Barakat, Noha Ahmed El-Boghdady, Ebtehal Kamal Eldin Farrag, Ataa Abdelhalim Said and Sylvia Edward Shaker
CNS Neuroscience & Therapeutics Negative regulation of glial Tim‐3 inhibits the secretion of inflammatory factors and modulates microglia to antiinflammatory phenotype after experimental intracerebral?… Pubmed: 30677253
International immunopharmacology NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro Pubmed: 30677569
博士论文 INSTITUTO DE CIENCIAS BÁSICAS Y PRECLÍNICAS “VICTORIA DE GIRÓN” DEPARTAMENTO DE HISTOLOGÍA
Life Sciences Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease
Cellular and Molecular Neurobiology Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke Pubmed: 30852719
Royal Society Open Science Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats
博士论文 6. Manuscript II: Evaluation of IL-1β levels in epilepsy and traumatic brain injury in dogs
Experimental Biology and Medicine Grape seed proanthocyanidin extract alleviates arsenic-induced lung damage through NF-κB signaling Pubmed: 30869553
Journal of Biological Sciences Protective and Curative Effects of Bombax ceiba Flower and Ziziphus spina christi Fruit Extracts on Gastric Ulcer
Journal of Animal Science Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation Pubmed: 30985866
Journal of Pineal Research Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice Pubmed: 30929267
Life Sciences 1, 25-(OH) 2D3 protects Schwann cells against advanced glycation end products-induced apoptosis through PKA-NF-κB pathway Pubmed: 30928409
Toxicon The wound healing potential of a pro-angiogenic peptide purified from Indian Russell's viper (Daboia russelii) venom Pubmed: 31054289
Mucosal Immunology Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization Pubmed: 31086271
The role of amniotic fluid exosome, hypoxia inducible fator-1α, and inflammatory cytokine in cervical insufficiency
pharmacological research Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ1 receptors Pubmed: 31048034
Stem Cell Reviews and Reports The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood Pubmed: 31089880
IUBMB Life Melatonin Enhances Autophagy and Decreases Apoptosis Induced by nanosilica in RAW264. 7 cells Pubmed: 31018046
Phytotherapy Research Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke‐induced airway inflammation Pubmed: 31209984
American Journal of Reproductive Immunology Effect of alpha lipoic acid and myoinositol on endometrial inflammasome from recurrent pregnancy loss women Pubmed: 31148259
BMC NEUROSCIENCE Evaluation of IL-1β levels in epilepsy and traumatic brain injury in dogs Pubmed: 31208341
Pharmacological Research Ethanol extracts of Danlou tablet attenuate atherosclerosis via inhibiting inflammation and promoting lipid effluent Pubmed: 31181336
Frontiers in Immunology Expression and Purification of Hybrid LL-37Tα1 Peptide in Pichia pastoris and evaluation of their Immunomodulatory and anti-inflammatory activities by LPS …
Food & Function Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats Pubmed: 31140472
Journal of the Royal Army Medical Corps CD28 deficiency attenuates primary blast-induced renal injury in mice via the PI3K/Akt signalling pathway Pubmed: 31129646
Metallomics Lanthanum chloride induces neuron damage by activating the nuclear factor-kappa B signaling pathway in activated microglia Pubmed: 31187842
Pinealektomize Edilmiş Septik Sıçanlarda TNF-α, IL-6, IL-10 ve IL-1β'nin Kan Düzeyleri ile Karaciğer ve Böbrekte Gen Ekspresyonu Seviyelerindeki … Doi: 10.5505/vtd.2019.32815
Journal of Neurochemistry Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury Pubmed: 31314915
Nature Chemical Biology S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate Pubmed: 31332308
neuroscience letters Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway Pubmed: 31330225
Free Radical Biology and Medicine Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat Pubmed: 31255668
Nanomedicine Antihyperuricemic and anti-gouty arthritis activities of Aurantii fructus immaturus carbonisata-derived carbon dots Pubmed: 31418646
Food & Function A dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese …
Inflammopharmacology Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function Pubmed: 31352642
Phytomedicine Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 …
Int Immunopharmacol Metallothionein-1 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells Pubmed: 31465913
Animals Anti-Inflammatory State in Arabian Horses Introduced to the Endurance Training Pubmed: 31462005
Frontiers in Pharmacology Naoxintong Capsule Inhibits the Development of Cardiovascular Pathological Changes in Bama Minipig Through Improving Gut Microbiota Pubmed: 31632272
International Journal of Molecular Sciences Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways Pubmed: 31590257
Scientific Reports Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus Pubmed: 31578381
Journal of Medicinal Food Polysaccharide from the Seeds of Plantago asiatica L. Protect Against Lipopolysaccharide-Induced Liver Injury Pubmed: 31560611
Molecular Medicine Reports High‑fat treatment prevents postoperative cognitive dysfunction in a hyperlipidemia model by protecting the blood‑brain barrier via Mfsd2a‑related signaling Pubmed: 31545471
Antioxidants Oxidative Stress, NF-κB-Mediated Inflammation and Apoptosis in the Testes of Streptozotocin–Induced Diabetic Rats: Combined Protective Effects of Malaysian … Pubmed: 31600920
LIFE SCIENCES Protective effects of epigallocatechin gallate against ischemia reperfusion injury in rat skeletal muscle via activating Nrf2/HO-1 signaling pathway Pubmed: 31678278
BMC Complementary and Alternative Medicine Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway Pubmed: 31747940
life sciences Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome Pubmed: 31738882
international journal of molecular sciences Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells Pubmed: 31671764
Journal of Controlled Release Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury Pubmed: 31783047
Journal of Food Science Effects of Total Flavonoids from Exocarpium Citri Grandis on Air Pollution Particle‐Induced Pulmonary Inflammation and Oxidative Stress in Mice Pubmed: 31762039
Cytokine Levels of pro-and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis Pubmed: 31927460
Journal of Photochemistry and Photobiology B Neuroprotective effect of Wogonin on Rat's brain exposed to gamma irradiation Pubmed: 31935591
Archives of Biochemistry and Biophysics Syringin protects against colitis by ameliorating inflammation Pubmed: 31899146
International Journal of Molecular Sciences Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet Pubmed: 31935892
Pharmacology Biochemistry and Behavior Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways Pubmed: 31899220
Frontiers in Immunology The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the … Pubmed: 31921131
Nutrients Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes Rats Pubmed: 31887996
GENES TO CELLS MiR‐29c‐3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease Pubmed: 32160394
Nanomedicine The toxicity of alumina nanoparticles to immune system in mice Pubmed: 32162999
Frontiers in Pharmacology Toddalolactone Protects Lipopolysaccharide-Induced Sepsis and Attenuates Lipopolysaccharide-Induced Inflammatory Response by Modulating HMGB1-NF … Pubmed: 32153412
Endocrine Glucagon-like peptide-2 analog and inflammatory state in obese mice Pubmed: 32172484
Biomed Pharmacother Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation Pubmed: 32106380
BRAIN BEHAVIOR AND IMMUNITY AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats Pubmed: 32097763
Frontiers in Microbiology Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase Pubmed: 32010088
Biomed Pharmacother Deletion of macrophage migration inhibitory factor ameliorates inflammation in mice model severe acute pancreatitis Pubmed: 32062385
Frontiers in Immunology TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation Pubmed: 32117301
JOURNAL OF HAZARDOUS MATERIALS Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction Pubmed: 32036317
Biomed Research International Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB … Pubmed: 32071922
Epilepsy Behav Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats Pubmed: 32000097
Archives of Biochemistry and Biophysics Micro RNA 146a gene variant/TNF-α/IL-6/IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke … Pubmed: 31738890
Oxidative Medicine and Cellular Longevity Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α2-Adrenergic Receptor-Dependent Suppression of Oxidative Stress Pubmed: 31827710
Medical Science Monitor MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 … Pubmed: 31710596
Molecular Therapy - Nucleic Acids Systematic transcriptome and regulatory network analyses reveal the hypoglycemic mechanism of Dendrobium fimbriatum Pubmed: 31790971
Chinese Journal of Natural Medicines Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats Pubmed: 32245593
International Journal of Molecular Medicine Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway Pubmed: 32236586
Journal of Pharmacy and Pharmacology Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin‐sensitized guinea pigs Pubmed: 32314371
veterinary research Newcastle disease virus RNA-induced IL-1β expression via the NLRP3/caspase-1 inflammasome Pubmed: 32293543
molecular immunology STAT5a induces endotoxin tolerance by alleviating pyroptosis in kupffer cells Pubmed: 32298872
journal of dairy science Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid–induced hepatic inflammation in dairy cows during early … Pubmed: 32278565
Inflammation Cyanidin-3-O-Glucoside Attenuates Lipopolysaccharide-Induced Inflammation in Human Corneal Epithelial Cells by Inducing Let-7b-5p-Mediated HMGA2/PI3K/Akt … Pubmed: 32248330
Pharmazie Anti-inflammatory effects of ginsenoside Rg3 on the hypertrophic scar formation via the NF-κB/IκB signaling pathway in rabbit ears Pubmed: 32213242
Marine Drugs Tu-Teng-Cao Extract Alleviates Monosodium Urate-Induced Acute Gouty Arthritis in Rats by Inhibiting Uric Acid and Inflammation Pubmed: 23306170
Nanomaterials An OMV-Based Nanovaccine Confers Safety and Protection against Pathogenic Escherichia coli via Both Humoral and Predominantly Th1 Immune Responses in … Pubmed: 33233490
LIFE SCIENCES Intravitreal conbercept improves outcome of proliferative diabetic retinopathy through inhibiting inflammation and oxidative stress Pubmed: 33227274
VETERINARY MICROBIOLOGY Upregulation of HMGB1 Secretion in Lungs of Pigs Infected by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Pubmed: 33221069
Exp Lung Res Ketogenic diet induces autophagy to alleviate bleomycin-induced pulmonary fibrosis in murine models Pubmed: 33121292
BIOMEDICINE & PHARMACOTHERAPY The influence of Potentilla chinensis aqueous extract on urinary bladder function in retinyl acetate-induced detrusor overactivity in rats Pubmed: 33113423
Cell Biochem Funct The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8‐Svneo cells Pubmed: 33079408
Neuroscience A new therapeutic strategy targeting protein deacetylation for spinal cord injury Pubmed: 33039524
J Diabetes Integrative analysis of hepatic metabolomic and transcriptomic data reveals potential mechanism of non‐alcoholic steatohepatitis in high‐fat diet‐fed mice Pubmed: 33022884
BIOMEDICINE & PHARMACOTHERAPY Chlorogenic acid prevents acute myocardial infarction in rats by reducing inflammatory damage and oxidative stress Pubmed: 33022535
DRUG AND CHEMICAL TOXICOLOGY Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats Pubmed: 33003960
Antioxidants Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro Pubmed: 32992548
Autophagy LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection Pubmed: 32924761
J Cell Mol Med LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway Pubmed: 32881263
Nanotoxicology miR-205/IRAK2 signaling pathway is associated with urban airborne PM2.5-induced myocardial toxicity Pubmed: 32880512
Drug Design Development and Therapy Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal … Pubmed: 32821084
Biochimie Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing Pubmed: 32800897
INVESTIGATIONAL NEW DRUGS Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors Pubmed: 32772342
Peptides Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway Pubmed: 32771373
Scientific Reports Beneficial effects of manually assisted chiropractic adjusting instrument in a rabbit model of osteoarthritis Pubmed: 32764579
Journal of Natural Medicines Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation … Pubmed: 32761488
MOLECULAR AND CELLULAR BIOCHEMISTRY MicroRNA-217 ameliorates inflammatory damage of endothelial cells induced by oxidized LDL by targeting EGR1 Pubmed: 32737769
Int Immunopharmacol BNIP3 deletion ameliorated enterovirus 71 infection-induced hand, foot and mouth disease via inhibiting apoptosis, autophagy, and inflammation in mice Pubmed: 32717566
BRAIN BEHAVIOR AND IMMUNITY Active smoking, sleep quality and cerebrospinal fluid biomarkers of neuroinflammation Pubmed: 32717405
molecular immunology TLR9 mediates the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation Pubmed: 32623292
Scientific Reports Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats Pubmed: 32616735
european journal of pharmacology The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis Pubmed: 32615180
Frontiers in Bioengineering and Biotechnology In vitro Impact of Yeast Expressed Hybrid Peptide CATH-2TP5 as a Prophylactic Measure Toward Sepsis and Inflammation Pubmed: 32582649
Journal of Neuroinflammation CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats Pubmed: 32532282
Frontiers in Pharmacology Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB … Pubmed: 32528295
Life Sci Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome Pubmed: 32526286
Brain and Behavior bFGF promotes neurological recovery from neonatal hypoxic–ischemic encephalopathy by IL‐1β signaling pathway‐mediated axon regeneration Pubmed: 32525289
American Journal of Translational Research Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and … Pubmed: 32509190
Frontiers in Pharmacology Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy Pubmed: 32508661
Clinical Oral Investigations Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort Pubmed: 32495225
STEM CELL REVIEWS AND REPORTS A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem … Pubmed: 32406006
Int J Mol Sci Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome Pubmed: 32403267
Int Immunopharmacol Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats Pubmed: 32402948
Molecular Biology Reports The effect of subacute poisoning with fenpropathrin on mice kidney function and the level of interleukin 1β and tumor necrosis factor α. Pubmed: 32385770
european journal of pharmaceutical sciences Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats Pubmed: 32360768
BIOSCIENCE REPORTS IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway Pubmed: 32347300
BIOMEDICINE & PHARMACOTHERAPY Protective effects of bee bread on testicular oxidative stress, NF-κB-mediated inflammation, apoptosis and lactate transport decline in obese male rats Pubmed: 33152939
ACS Chemical Neuroscience α-Synuclein Exhibits Differential Membrane Perturbation, Nucleation, and TLR2 Binding through Its Secondary Structure Pubmed: 33196165
Nutrition Changes in peripheral inflammation-related gene expression by postprandial glycemic response in healthy Japanese men Pubmed: 33131984
Journal of Diabetes Research Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus Pubmed: 33123597
International Immunopharmacology Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway Pubmed: 33182056
Biomedicine & Pharmacotherapy Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12 … Pubmed: 32559840
European Review for Medical and Pharmacological Sciences Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and … Pubmed: 32432773
Domestic Animal Endocrinology A Preliminary Evaluation of the Circulating Leptin/Adiponectin Ratio in Dogs with Pituitary-Dependent Hyperadrenocorticism and concurrent diabetes mellitus Pubmed: 32920447
Biomedicine & Pharmacotherapy Qingfei oral liquid alleviates airway hyperresponsiveness and mucus hypersecretion via TRPV1 signaling in RSV-infected asthmatic mice Pubmed: 32521453
International Journal of Nanomedicine Effect of Lonicerae japonicae Flos Carbonisata-Derived Carbon Dots on Rat Models of Fever and Hypothermia Induced by Lipopolysaccharide Pubmed: 32606669
Frontiers in Pharmacology O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to … Pubmed: 32733244
Inflammation Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways
Indian Journal of Animal Sciences Peripheral concentrations of metabolic and inflammatory indicators during transition period and their relationship with postpartum clinical endometritis in dairy …
Food & Function Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial …
Food and Agricultural Immunology Acrylamide induced the activation of NLRP3 inflammasome via ROS-MAPKs pathways in Kupffer cells
Nanoscale Research Letters Protective Effects of Carbon Dots Derived from Phellodendri Chinensis Cortex Carbonisata against Deinagkistrodon acutus Venom-Induced Acute Kidney …
Journal of Biochemical and Molecular Toxicology Vitamin D3 and calcium cosupplementation alleviates cadmium hepatotoxicity in the rat: Enhanced antioxidative and anti‐inflammatory actions by remodeling cellular …
Biotechnology & Biotechnological Equipment Honokiol inhibits inflammation and endoplasmic reticulum stress in a rat model of pregnancy-induced hypertension
Journal of Functional Foods Wine pomace product modulates oxidative stress and microbiota in obesity high-fat diet-fed rats
Journal of Functional Foods Polyphenolic extracts from Wushan tea leaves attenuate hepatic injury in CCl4-treated mice
Microbiome changes in patients with chronic heart failure with preserved ejection fraction correlate with fibrosis markers: Description of a Russian cohort
Iranian Journal of Allergy, Asthma and Immunology Increased Level of Caspase-1 in the Serum of Relapsing-remitting Multiple Sclerosis (RRMS) Patients
Interferon regulatory factor 8 induces alveolar macrophage hypoxia/reoxygenation injury via the PINK1/Parkin mitophagy pathway
Phytomedicine Menthacarin attenuates experimental colitis
ACS Biomaterials Science & Engineering Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction
The Role of Inflammatory Cytokine and Inflammatory Regulator Protein Related to Severity of Joint Effusion in Osteoarthritis
Tempuyung Leaves (Sonchus arvensis) Ameliorates Monosodium Urate Crystal-Induced Gouty Arthritis in Rats through Anti-Inflammatory Effects
Overektomize dişi sıçanlarda beyin oksidatif stres, bdnf ve inflamatuar cevap düzeyleri ile nörodavranışsal değişiklikler üzerine anjiyotensin II İnhibisyonunun etkisi
Drug Dev Res Paeoniflorin inhibited nod©\like receptor protein©\3 inflammasome and NF©\¦ÊB©\mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine?¡­ 33236457
Respir Physiol Neurobiol Protective effect of Toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress?¡­ 33333238
Scientific Reports Immunogenicity and protective efficacy of enterotoxigenic Escherichia coli (ETEC) total RNA against ETEC challenge in a mouse model 33239756
Nutrients AphaMax?, an Aphanizomenon Flos-Aquae Aqueous Extract, Exerts Intestinal Protective Effects in Experimental Colitis in Rats 33256017
Bull Exp Biol Med Inflammation Mediators Regulate the Microbiota Resistance to Adverse Factors 33222085
Int J Mol Med Astragaloside IV alleviates silica?induced pulmonary fibrosis via inactivation of the TGF?¦Â1/Smad2/3 signaling pathway 33448318
Biochem Pharmacol Inactivation of Wnt/¦Â-catenin/renin angiotensin axis by tumor necrosis factor-alpha inhibitor, infliximab, ameliorates CKD induced in rats 33482150
Stem Cell Reviews and Reports Prospects on the Potential In Vitro Regenerative Features of Mechanically Treated-Adipose Tissue for Osteoarthritis Care 33469783
EUROPEAN JOURNAL OF PHARMACOLOGY Gliclazide alters macrophages polarization state in diabetic atherosclerosis in vitro via blocking AGE-RAGE/TLR4-reactive oxygen species-activated NF-k¦Â nexus 33460615
Molecules Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion 33430011
MEDIATORS OF INFLAMMATION MMP-9 Concentration in Peritoneal Fluid Is a Valuable Biomarker Associated with Endotoxemia in Equine Colic 33488296
Mol Cell Biochem Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium¨Cglucose cotransporter 1 33608832
Life Sci Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats 33577848
Life Sci Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice 33508297
Animal Effect of alfalfa hay and starter feed supplementation on caecal microbiota and fermentation, growth, and health of yak calves 33610512
european journal of clinical nutrition? Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury 33514869
Int Immunopharmacol Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target 33677255
Tissue Cell Protective effects of Oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation 33676236
bmc pediatrics Factors associated with neurodevelopment in preterm infants with systematic inflammation 33685414
INFLAMMATION Acid Sphingomyelinase and Acid ¦Â-Glucosidase 1 Exert Opposite Effects on Interleukin-1¦Â-Induced Interleukin 6 Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes 33665756
JOURNAL OF PERIODONTAL RESEARCH Potential biomarkers reflecting inflammation in patients with severe periodontitis: Fractalkine (CX3CL1) and its receptor (CX3CR1) 33641164
Biochem Cell Biol Formononetin protects against concanavalin-A-induced autoimmune hepatitis in mice through its anti-apoptotic and anti-inflammatory properties 33749318
J Physiol Biochem Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis 33886081
Hum Exp Toxicol Alamandine significantly reduces doxorubicin-induced cardiotoxicity in rats 33882726
NEUROSCIENCE RESEARCH Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats 33785408
FASEB Bioadv Cyclophilin A induces macrophage apoptosis and enhances atherosclerotic lesions in high©\fat diet©\fed hyperglycemic rabbits 33977232
Arch Biochem Biophys Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats 33965368
Randomized Controlled Trial Effect of Freeze-Dried Amnion Graft on Cytokines in Uterine Exudates Following Hysteroscopic Adhesiolysis of Severe Intrauterine Adhesions 28170094
Orthop Surg Proline©\Serine¨CThreonine Phosphatase©\Interacting Protein 2 Alleviates Diabetes Mellitus©\Osteoarthritis in Rats through Attenuating Synovial Inflammation and?¡­ 33939302
Biomed Pharmacother Captopril downregulates expression of Bax/cytochrome C/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute?¡­ 33945910
PLoS One Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment¡ªIn vivo studies 33999928
Nephron Dexmedetomidine Exerts Renal Protective Effect by Regulating the PGC-1¦Á/STAT1/IRF-1 Axis 33965939
Stem Cell Research & Therapy Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung?¡­ 33933128
BMC Pharmacology & Toxicology Subacute poisoning with bifenthrin increases the level of interleukin 1? in mice kidneys and livers 33902677
Clin Oral Investig Evaluation of heat shock protein 70 and toll-like receptor 4 expression in gingival crevicular fluid in response to orthodontic forces 34091792
Placenta Vitamin D alleviates hypoxia/reoxygenation-induced injury of human trophoblast HTR-8 cells by activating autophagy 34126416
Chem Biol Interact Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy 34051206
Med Sci Monit Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating ¡­ 34059615
Exp Eye Res Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation 34144035
BioMed Research International Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves?¡­ 33376718
Evidence-Based Complementary and Alternative Medicine Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling?¡­ 33505502
Basic and Clinical Neuroscience Paeonol Protects Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease 33995926
BioMed Research International MiR-599 Protects Cardiomyocytes against Oxidative Stress-Induced Pyroptosis 33681353
cells The Effect of the Clenbuterol¡ª¦Â2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen?¡­ 33920705
Antioxidants Hidrox? Roles in Neuroprotection: Biochemical Links between Traumatic Brain Injury and Alzheimer's Disease 34065584
Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR¦Á/NF-¦ÊB signaling pathways 34162146
Natural Product Communications Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model
Journal of Alzheimer's disease DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Up-regulating cAMP/PKA/CREB?¡­
researchsquare p62 promotes HIV-1 gp120 V3 loop-mediated microglial inflammation by promoting noncanonical activation of Nrf2
Berberine Attenuates Neonatal Sepsis in Rats By Inhibiting FOXA1 and NF-¦ÊB Signaling Transduction Via The Induction of miR-132-3p
biomolecules Treadmill Running Changes Endothelial Lipase Expression: Insights from Gene and Protein Analysis in Various Striated Muscle Tissues and Serum
Antioxidants Oxidative Stress Mediates Vascular Tortuosity
Peptides Angiotensin-(1-7) protects against sepsis-associated left ventricular dysfunction induced by lipopolysaccharide 34298021
Cancer Lett Photodynamic therapy induces human esophageal carcinoma cell pyroptosis by targeting the PKM2/caspase-8/caspase-3/GSDME axis 34256094
J Pharm Pharmacol Alamandine protects against renal ischaemia–reperfusion injury in rats via inhibiting oxidative stress 34244746
Food Chem Toxicol GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies 34197882
Front Pharmacol In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis 34177580
J Cell Mol Med Puerarin attenuates intracerebral hemorrhage‐induced early brain injury possibly by PI3K/Akt signal activation‐mediated suppression of NF‐κB pathway 34180121
Aging Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular … 34315133
Peptides Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways 34400214
J Neuroinflammation Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia–reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway 34362408
Medicine (Baltimore) Clinical value of CD97 and CD55 levels in the differential diagnosis of tuberculous and malignant pleural effusions 34397724
Mol Med Rep Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway 34296299
J Asthma Clinical and Biological Indicators of Periodontal Disease in Obese and non-Obese adults with and without Bronchial Asthma 34324826
Int Immunopharmacol The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages 34332342
Inflammation Berberine Attenuates Neonatal Sepsis in Mice By Inhibiting FOXA1 and NF-κB Signal Transduction Via the Induction of MiR-132-3p 34523052
Mol Med Rep Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1 34498715
Int Immunopharmacol Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway 34464887
JOURNAL OF PHARMACY AND PHARMACOLOGY Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin–angiotensin axis 34549301
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Chronic developmental exposure to low-dose ([C8mim][PF6]) induces neurotoxicity and behavioural abnormalities in rats 34555716
BIOMEDICINE & PHARMACOTHERAPY Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: Targeting oxidative stress, energy deficit and spermatogenesis 34560547
Cell Metabolism Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species 34536344
Food Chem Toxicol Anti-inflammatory action of betulin and its potential as a dissociated glucocorticoid receptor modulator 34500009
Neurosci Lett Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice 34500002
Int J Biochem Cell Biol Impact of Type 2 Diabetes Mellitus on the Immunoregulatory Characteristics of Adipose Tissue-Derived Mesenchymal Stem Cells 34455058
Int Immunopharmacol Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis 34450401
Biochim Biophys Acta Mol Cell Biol Lipids Elaidic acid induced NLRP3 inflammasome activation via ERS-MAPK signaling pathways in Kupffer cells 34610469
CNS Neurosci Ther Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke 34591349
Med Pharm Rep Effects of the Sonchus Arvensis Fraction in Rats with Monosodium Urate–Induced Gouty Arthritis 34430859
J Periodontol Cytokine profile in serum and gingival crevicular fluid of children with inflammatory bowel disease: A case‐control study 34730850
J Agric Food Chem Allicin Ameliorates Intestinal Barrier Damage via Microbiota-Regulated Short-Chain Fatty Acids-TLR4/MyD88/NF-κB Cascade Response in Acrylamide-Induced Rats 34694121
Inflammation The Role of IL-27 in the Systemic Inflammatory Response That Accompanies Preterm Labour 34773188
Biofactors Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat 34767670
Inflamm Res Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway 34767031
J Ethnopharmacol Bai-Hu-Tang regulates endothelin-1 and its signalling pathway in vascular endothelial cells 34752899
Biomaterials 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model 34739982
Korean J Physiol Pharmacol Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole 34697261
Neurosci Let Fingolimod protects against cerebral ischemia reperfusion injury in rats by reducing inflammatory cytokines and inhibiting the activation of p38 MAPK and NF-κB … 34942319
Animals (Basel) Inflammatory markers in uterine lavage fluids of pregnant, non-pregnant, and intrauterine device implanted mares on Days 10 and 15 post ovulation 34944269
Alzheimers Res Ther Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and … 34844651
World J Gastroenterol Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation 34908806
Experimental and Therapeutic Medicine Autonomic regulation of imbalance‑induced myocardial fibrosis and its mechanism in rats with cirrhosis 34373726
Food Science & Technology Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin‐induced inflammatory response in rats cotreated with … 34646510
Pharmaceutics Nitric-Oxide-Releasing Dexamethasone Derivative NCX-1005 Improves Lung Function and Attenuates Inflammation in Experimental Lavage-Induced ARDS 34959373
Viruses Interleukin-10-Mediated Lymphopenia Caused by Acute Infection with Foot-and-Mouth Disease Virus in Mice 34960627
Eur J Pharm Sci Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment 34314841
Toxicology Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress 34450210
Animal Nutrition Optimizing the growth and immune system of dairy calves by subdividing the pre-weaning period and providing different milk volumes for each stage 34786502
Antioxidants Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer's Disease 34829535
Mol Med Rep Long non-coding RNA NEAT1 participates in ventilator-induced lung injury by regulating miR-20b expression Pubmed:34981816
Anesthesiology Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits Pubmed:34965287
J Mol Neurosci TRPV1 Suppressed NLRP3 Through Regulating Autophagy in Microglia After Ischemia-Reperfusion Injury Pubmed:35041191
J Inflamm Res Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice Pubmed:35058704
Int J Nanomedicine Protective Effects of Carbon Dots Derived from Armeniacae Semen Amarum Carbonisata Against Acute Lung Injury Induced by Lipopolysaccharides in Rats Pubmed:35023915
Poult Sci Hypervirulent FAdV-4 infection induces activation of the NLRP3 inflammasome in chicken macrophages Pubmed:35077922
Animals (Basel) Inflammatory Markers in Uterine Lavage Fluids of Pregnant, Non-Pregnant, and Intrauterine Device Implanted Mares on Days 10 and 15 Post Ovulation … Pubmed:34944269
Bioengineered Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway Pubmed:35168476
J Biochem Mol Toxicol Silencing of IGF2BP1 restrains ox‐LDL‐induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages Pubmed:35179253
Toxicology NaF-induced neurotoxicity via activation of the IL-1β/JNK signaling pathway Pubmed:35172196
Ecotoxicol Environ Saf Silica nanoparticles induce pulmonary autophagy dysfunction and epithelial-to-mesenchymal transition via p62/NF-κB signaling pathway Pubmed:35158278
FASEB J proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines Pubmed:35129860
Cell Death Discov Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury Pubmed:35110526
Chin Med Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation … Pubmed:35078487
J Dairy Sci Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease Pubmed:35086715
Exp Biol Med (Maywood) Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat Pubmed:35068213
Peptides Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress Pubmed:35218795
Int Immunopharmacol LncRNA KCNQ1OT1 attenuates myocardial injury induced by hip fracture via regulating of miR-224-3p/GATA4 axis Pubmed:35217336
Antioxidants (Basel) Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats Pubmed:35326164
PLoS One Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology … Pubmed:35235611
Free Radic Biol Med Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway Pubmed:35219847
Molecular Biotechnology MiR-199a-3p Restrains Foaming and Inflammation by Regulating RUNX1 in Macrophages Pubmed:35435591
International Heart Journal Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis Pubmed:35354753
Journal of Integrative Neuroscience Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway Pubmed:35364660
Neurochem Res Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model Pubmed:35426598
Inflammopharmacology Silymarin constrains diacetyl-prompted oxidative stress and neuroinflammation in rats: involvements of Dyn/GDNF and MAPK signaling pathway Pubmed:35366745
Evid Based Complement Alternat Med Loureirin B Alleviates Myocardial Ischemia/Reperfusion Injury via Inhibiting PAI-1/TGF-β1/Smad Signaling Pathway Pubmed:35535157
Perfusion Insulin reduces pyroptosis-induced inflammation by PDHA1 dephosphorylation-mediated NLRP3 activation during myocardial ischemia-reperfusion injury Pubmed:35506656
Eur J Pharmacol Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol … Pubmed:35500641
J Clin Med Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study Pubmed:35566605
Expert Opinion on Therapeutic Targets Dapagliflozin mitigates ovalbumin-prompted airway inflammatory-oxidative successions and associated bronchospasm in a rat model of allergic asthma Pubmed:35549595
American Journal of Translational Research Curcumin treats endometriosis in mice by the HIF signaling pathway Pubmed:35559378
Mol Immunol Oridonin alleviates kanamycin-related hearing loss by inhibiting NLRP3/caspase-1/gasdermin D-induced inflammasome activation and hair cell pyroptosis Pubmed:35749835
J Biomed Mater Res B Appl Biomater Hybrid system with stable structure of hard/soft tissue substitutes induces re‐osseointegration in a rat model of biofilm‐mediated peri‐implantitis Pubmed:35620882
Ecotoxicol Environ Saf Ambient ozone exposure induces ROS related-mitophagy and pyroptosis via NLRP3 inflammasome activation in rat lung cells Pubmed:35642860
Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19 Pubmed:35110086
Poultry Science Modulation of the innate immune system by lipopolysaccharide in the proventriculus of chicks inoculated with or without Newcastle disease and infectious … Pubmed:35247652
Antioxidants Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory … Pubmed:35204215
Antioxidants Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model … Pubmed:35204140
Oxidative Medicine and Cellular Longevity The Role of Aeromonas-Goblet Cell Interactions in Melatonin-Mediated Improvements in Sleep Deprivation-Induced Colitis Pubmed:35355860
Oxidative Medicine and Cellular Longevity Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the … Pubmed:35360200
Veterinary World Pro-inflammatory cytokine release from chicken peripheral blood mononuclear cells stimulated with lipopolysaccharide Pubmed:35698506
Glycation renders alpha-synuclein oligomeric strain and modulates microglia activation
Pyroptosis Accelerates Spiral Ganglion Neuronal Degeneration Induced by Aminoglycosides in the Cochlea
researchsquare Dexmedetomidine Attenuates Hyperalgesia Induced By Brachial Plexus Root Avulsion By Restoring The GLT-1 Function Via PKA Signaling
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