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Cavia Model for Motor Neuron Disease (MND)

  • Product No.DSI824Gu01
  • Organism SpeciesCavia (Guinea pig ) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by immunized with purified bovine spinal cord anterior horn motor neurons
  • Model Animal StrainsGuinea pig, male, healthy, body weight: 480~500g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period16w~18w
  • Modeling Method1. Guinea pigs were immunized with fresh bovine spinal cord anterior horn homogenate, and 10 parts were injected subcutaneously at the back of the guinea pigs, each time for 4 weeks, for a total of 5 times.
    2. The changes of light microscope and ultrastructure of spinal cord: anterior root and sciatic nerve were observed. Results the weight of guinea pigs decreased significantly after fourth immunization. Degeneration and loss of motor neurons in the anterior horn of the spinal cord.
  • ApplicationsDisease Model
  • Downloadn/a
  • UOM Each case
  • FOB US$ 300 
    For more details, please contact local distributors!

Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Cavia (Guinea pig ) Organism species Applications (RESEARCH USE ONLY!)
DSI824Gu01 Cavia Model for Motor Neuron Disease (MND) Disease Model