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Rat Model for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

OSA; Obstructive Sleep Apnea

  • Product No.DSI813Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • Prototype SpeciesHuman
  • Sourceinjection of sodium hyaluronate to palatoglossal arch, pharyngopalatine arch and tongue
  • Model Animal StrainsWistar Rats (SPF ), male, 200g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1d~3d
  • Modeling Method1. Anesthesia: pentobarbital sodium with sterile saline with 0.8% sodium pentobarbital solution. Intraperitoneal injection of different doses was performed during operation and sleep monitoring.
    2. injection of sodium hyaluronate in rats after anesthesia, to the bilateral lingual palatal arch, pharyngopalatine arch and tongue till the rats appear apnea,
    3. Acquisition of the signal: monitoring the electroencephalogram(EEG), electromyogram(EMG) and the muzzle flow (oro-nasal, AIRFLOW) of a patient with a modified multi - Sleep apparatus.
    4. Analysis of signals: EEG, EMG, and muzzle airflow.
  • ApplicationsDisease Model
  • Downloadn/a
  • UOM Each case
  • FOB US$ 280 
    For more details, please contact local distributors!

Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
DSI813Ra01 Rat Model for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Disease Model