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Rat Model for Ocular Ischemic Syndrome (OIS)

  • Product No.DSI807Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by bilateral common carotid artery ligation
  • Model Animal StrainsBN rats (SPF), age: 3 months
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4~6 weeks
  • Modeling Method1. Rats were fasted before 8~12h, free drinking water. Intraperitoneal injection of 1% pentobarbital sodium 40mg/kg weight, lying on the back of the neck, make a 2~3cm incision, carefully separate the skin and muscles.
    2. Blunt dissection of the carotid artery in front of the neck muscle and lateral muscle gap and make a ligation of the carotid artery with a silk thread of 3-0. After suturing the skin from alcohol to disinfect the wound.
  • ApplicationsDisease Model
  • Downloadn/a
  • UOM Each case
  • FOB US$ 240 
    For more details, please contact local distributors!

Model Evaluation

1. Observe the pupillary light reflex in rats after modeling for 1 months;
2. One months after operation, the rats were examined by color fundus photography and fundus fluorescein angiography (FFA) examination of the fundus of the eye;
3. The rats were sacrificed to obtain the retina and the changes of retinal structure were detected by transmission electron microscope.

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
DSI807Ra01 Rat Model for Ocular Ischemic Syndrome (OIS) Disease Model