Mouse Model for Secretory Otitis Media (SOM)
- Product No.DSI580Mu01
- Organism SpeciesMus musculus (Mouse) Same name, Different species.
- Prototype SpeciesHuman
- SourceOVA secretory otitis media
- Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g
- Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
- Modeling Period4-6 weeks
- Modeling MethodBALB/c mice, weight: 25 ~ 30g, age 6 ~ 8 weeks, erythrhea reflect the sensitively, confirmed by earoscopy no external ear canal and middle ear infection. BALB/c mice were given 1.2 mg of ovalbumin (OVA) in 0.6 ml of phosphate buffer (PBS) and intraperitoneally with 5.14 mg of aluminum hydroxide as an adjuvant for 1 week/2 weeks Sensitization; 2 weeks after the dose of 5 ml / kg body weight by intraperitoneal injection of 20% Uralan anesthesia, aseptic technique 1g / L oVA + PBS mixture 15ul before the tympanic membrane into the tympanum, 24 h after the mouse again Anesthesia, observe the tympanic membrane state, and repeated injection 2 times, ear stimulation; caused by secretory otitis media model. The model animals were subjected to otoscopy every day after injection of OVA solution. The mice were sacrificed 2 days after the second challenge. The thickness of the middle mucosa was measured by HE staining and the eosinophils Cells, plasma cells, toluidine blue staining mast cells.
- Applicationsn/a
- Downloadn/a
- UOM Each case
- FOB
US$
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Model Evaluation
Pathological Results
Cytokines Level
Statistical Analysis
SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.
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Catalog No. | Related products for research use of Mus musculus (Mouse) Organism species | Applications (RESEARCH USE ONLY!) |
DSI580Mu01 | Mouse Model for Secretory Otitis Media (SOM) | n/a |