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Mouse Model for Secretory Otitis Media (SOM)

  • Product No.DSI580Mu01
  • Organism SpeciesMus musculus (Mouse) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceOVA secretory otitis media
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
  • Modeling MethodBALB/c mice, weight: 25 ~ 30g, age 6 ~ 8 weeks, erythrhea reflect the sensitively, confirmed by earoscopy no external ear canal and middle ear infection. BALB/c mice were given 1.2 mg of ovalbumin (OVA) in 0.6 ml of phosphate buffer (PBS) and intraperitoneally with 5.14 mg of aluminum hydroxide as an adjuvant for 1 week/2 weeks Sensitization; 2 weeks after the dose of 5 ml / kg body weight by intraperitoneal injection of 20% Uralan anesthesia, aseptic technique 1g / L oVA + PBS mixture 15ul before the tympanic membrane into the tympanum, 24 h after the mouse again Anesthesia, observe the tympanic membrane state, and repeated injection 2 times, ear stimulation; caused by secretory otitis media model. The model animals were subjected to otoscopy every day after injection of OVA solution. The mice were sacrificed 2 days after the second challenge. The thickness of the middle mucosa was measured by HE staining and the eosinophils Cells, plasma cells, toluidine blue staining mast cells.
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  • UOM Each case
  • FOB US$  
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Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Mus musculus (Mouse) Organism species Applications (RESEARCH USE ONLY!)
DSI580Mu01 Mouse Model for Secretory Otitis Media (SOM) n/a