Rat Model for Tourette Syndrome (TS)
Tourette's
- Product No.DSI550Ra01
- Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
- Prototype SpeciesHuman
- SourceInduced by 3,3 '-iminodipropionitrile(IDPN)
- Model Animal StrainsSD Rats(SPF), healthy, male, bodyweight:180g~200g
- Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group (Tiapride Hydrochloride )and Test drug group (three doses) n=15.
- Modeling Period7d
- Modeling Method1. The rats were injected intraperitoneally with 3,3 '-iminodipropionitrile(IDPN), and the dose: 300 mg/(kg.d) for continuous administration for 7 days.
2. After modeling, the rats were given intragastric administration at the same time every morning. The blank group and model group were given normal saline. The intragastric dose was 1mL/100g. - ApplicationsUsed to screen drugs for preventing and treatment for Tourette Syndrome
- Downloadn/a
- UOM Each case
- FOB
For more details, please contact local distributors! US$ 200
Model Evaluation
Behavioral experiment evaluation criteria
1. Motion behavior assessment standard:
0 points: quiet or normal activity;
1 points: over excited;
2 points: increase the behavior of inquiry, non continuous nasal suction;
3 points: keep running;
4 points: stop running with startle.
2. Stereotyped behavior assessment standard: according to the Diamond score
0 points: no stereotyped movement;
1 points: the body rotation behavior (rotation clockwise or counterclockwise);
2 points: head and neck movement up and down too much (an abnormal movement of head and neck and vertical direction);
3 points: head and neck movement up and down too much and rotating motion;
4 points: head to the side of the pendulum, with head and neck movement up and down too much.
Behavioral assessment time: the behavioral experiment was performed every other day for 7 days after modeling, and a total of 5 behavioral tests were performed.
Pathological Results
Cytokines Level
Dopamine(DA), Dopamine receptor 2(D2R):
After the last administration of fasting but free drinking water at night, 5 rats in each group were randomly selected, after the end of the blood into the EDTA anticoagulant tube, frozen centrifugation (3000 rpm, 10 minutes), take the supernatant stored at -80℃.
ELISA kit was used to detect the content of DA and D2R in serum and striatum
Statistical Analysis
SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.
GIVEAWAYS
INCREMENT SERVICES
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Tissue/Sections Customized Service
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Serums Customized Service
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Immunohistochemistry (IHC) Experiment Service
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Small Animal Micro CT Imaging Experiment Service
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Small Animal MRI Imaging Experiment Service
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Small Animal Ultrasound Imaging Experiment Service
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Transmission Electron Microscopy (TEM) Experiment Service
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Scanning Electron Microscope (SEM) Experiment Service
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Learning and Memory Behavioral Experiment Service
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Anxiety and Depression Behavioral Experiment Service
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Drug Addiction Behavioral Experiment Service
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Pain Behavioral Experiment Service
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Neuropsychiatric Disorder Behavioral Experiment Service
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Fatigue Behavioral Experiment Service
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Nitric Oxide Assay Kit (A012)
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Nitric Oxide Assay Kit (A013-2)
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Total Anti-Oxidative Capability Assay Kit(A015-2)
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Total Anti-Oxidative Capability Assay Kit (A015-1)
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Superoxide Dismutase Assay Kit
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Fructose Assay Kit (A085)
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Citric Acid Assay Kit (A128 )
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Catalase Assay Kit
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Malondialdehyde Assay Kit
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Glutathione S-Transferase Assay Kit
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Microscale Reduced Glutathione assay kit
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Glutathione Reductase Activity Coefficient Assay Kit
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Angiotensin Converting Enzyme Kit
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Glutathione Peroxidase (GSH-PX) Assay Kit
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Cloud-Clone Multiplex assay kits
Catalog No. | Related products for research use of Rattus norvegicus (Rat) Organism species | Applications (RESEARCH USE ONLY!) |
DSI550Ra01 | Rat Model for Tourette Syndrome (TS) | Used to screen drugs for preventing and treatment for Tourette Syndrome |