![Protein Nef, HIV2 (Nef)](/upload/item/img/Protein-Nef--HIV2-(Nef)-X339.png)
The human immunodeficiency virus (HIV) accessory protein Nef plays a major role in establishing and maintaining infection, particularly through immune evasion. Many HIV-2 infected people experience long-term viral control and survival, similar to HIV-1 elite control. HIV-2 Nef and HIV-1 Nef have overlapping but distinct functions. In primates and humans, deletions in Nef are clearly associated with low viral load and delayed disease progression. HIV-1 and HIV-2 Nef down-regulate membrane proteins such as CD3, CD4 and CD28, up-regulate Fas proteins on infected cells, and regulate signaling pathways through interaction with kinases. However, HIV-2 Nef uses its C-terminal region, which is absent in HIV-1 Nef, to down-regulate MHC Class I molecules by binding to the AP-1 complex.
Organism species: Pan-species (General)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protein Nef, HIV2 (Nef) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protein Nef, HIV2 (Nef) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protein Nef, HIV2 (Nef) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protein Nef, HIV2 (Nef) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protein Nef, HIV2 (Nef) | ELISA Kit Customized Service Offer |