Sin3A Associated Protein 25kDa (SAP25)
[Edit]25 kDa Sin3-associated polypeptide; Histone deacetylase complex subunit SAP25; Sin3 corepressor complex subunit SAP25
![Sin3A Associated Protein 25kDa (SAP25)](/upload/item/img/Sin3A-Associated-Protein-25kDa-(SAP25)-70833.gif)
SAP25 binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA. SAP25 is required for mSin3A-mediated, but not N-CoR-mediated, repression. SAP25 is a nucleocytoplasmic shuttling protein, actively exported from the nucleus by a CRM1-dependent mechanism. A fraction of SAP25 is located in promyelocytic leukemia protein (PML) nuclear bodies, and PML induces a striking nuclear accumulation of SAP25. An isotope-coded affinity tag quantitative proteomic analysis of the SAP25 complex revealed that SAP25 is associated with several components of the mSin3 complex, nuclear export machinery, and regulators of transcription and cell cycle. SAP25 is a novel core component of the mSin3 corepressor complex whose subcellular location is regulated by PML.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sin3A Associated Protein 25kDa (SAP25) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sin3A Associated Protein 25kDa (SAP25) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sin3A Associated Protein 25kDa (SAP25) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sin3A Associated Protein 25kDa (SAP25) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sin3A Associated Protein 25kDa (SAP25) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sin3A Associated Protein 25kDa (SAP25) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sin3A Associated Protein 25kDa (SAP25) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sin3A Associated Protein 25kDa (SAP25) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sin3A Associated Protein 25kDa (SAP25) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sin3A Associated Protein 25kDa (SAP25) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex."Mol. Cell. Biol. 26:1386-1397(2006) [PubMed] [Europe PMC] [Abstract]