Geminin Coiled Coil Domain Containing Protein 1 (GEMC1)

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GMNC

Geminin Coiled Coil Domain Containing Protein 1 (GEMC1)
GEMC1, a novel vertebrate protein required for chromosomal DNA replication. GEMC1 is highly conserved in vertebrates and is preferentially expressed in proliferating cells. Xenopus GEMC1 binds to the checkpoint and replication factor TopBP1, which promotes binding of xGEMC1 to chromatin during pre-replication complex formation. xGEMC1 interacts directly with replication factors such as Cdc45 and the kinase Cdk2-CyclinE, through which it is heavily phosphorylated. Phosphorylated xGEMC1 stimulates initiation of DNA replication, whereas depletion of xGEMC1 prevents the onset of DNA replication owing to the impairment of Cdc45 loading onto chromatin. GEMC1 promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2-dependent recruitment of Cdc45 onto replication origins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Polyclonal Antibody Customized Service Offer
Assay Kits SEW830Hu ELISA Kit for Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Geminin Coiled Coil Domain Containing Protein 1 (GEMC1) ELISA Kit Customized Service Offer
  1. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]