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KAT8 Regulatory NSL Complex Subunit 1 (KANSL1)

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MSL1v1; NSL1; CENP36; Centromere Protein 36; MLL1/MLL complex subunit KANSL1; MSL1 homolog 1; NSL complex protein NSL1; Non-specific lethal 1 homolog

KAT8 Regulatory NSL Complex Subunit 1 (KANSL1)
CCC W797
HGNC 24565
MGI 1923969
UniProt Q7Z3B3
In mammals, MYST family histone acetyltransferase MOF plays important roles in transcription activation by acetylating histone H4 on K16, a prevalent mark associated with chromatin decondensation, and transcription factor p53 on K120, which is important for activation of pro-apoptotic genes. However, little is known about MOF regulation in higher eukaryotes. The acetyltransferase activity of MOF is tightly regulated in two different but evolutionarily conserved complexes, MSL and MOF-MSL1v1. While the two MOF complexes have indistinguishable activity on histone H4 K16, they differ dramatically in acetylating non-histone substrate p53. MOF-MSL1v1 is specifically required for optimal transcription activation of p53 target genes both in vitro and in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for KAT8 Regulatory NSL Complex Subunit 1 (KANSL1) ELISA Kit Customized Service Offer
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