![G Antigen 12F (GAGE12F)](/upload/item/img/G-Antigen-12F-(GAGE12F)-70590.gif)
GAGE12F belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells.
The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.3 presented a new GAGE gene nomenclature based on the identified genes and their products.
The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.3 presented a new GAGE gene nomenclature based on the identified genes and their products.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant G Antigen 12F (GAGE12F) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to G Antigen 12F (GAGE12F) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to G Antigen 12F (GAGE12F) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for G Antigen 12F (GAGE12F) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for G Antigen 12F (GAGE12F) | ELISA Kit Customized Service Offer |
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]