Paralog Of XRCC4 And XLF (PAXX)

[Edit]

C9orf142; Chromosome 9 Open Reading Frame 142

Paralog Of XRCC4 And XLF (PAXX)
Chromosome 9 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome, as they normally do with all chromosomes.
Chromosome 9 spans about 145 million base pairs of nucleic acids (the building blocks of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. Deletions of part or all of chromosome 9 are commonly found in bladder cancers. These chromosomal changes are seen only in cancer cells and typically occur early in tumor formation. Researchers believe that several genes that play a role in bladder cancer may be located on chromosome 9. They suspect that these genes may be tumor suppressors, which means they normally help prevent cells from growing and dividing in an uncontrolled way.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paralog Of XRCC4 And XLF (PAXX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paralog Of XRCC4 And XLF (PAXX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paralog Of XRCC4 And XLF (PAXX) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paralog Of XRCC4 And XLF (PAXX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paralog Of XRCC4 And XLF (PAXX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paralog Of XRCC4 And XLF (PAXX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paralog Of XRCC4 And XLF (PAXX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paralog Of XRCC4 And XLF (PAXX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paralog Of XRCC4 And XLF (PAXX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paralog Of XRCC4 And XLF (PAXX) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair."Science 347:185-188(2015) [PubMed] [Europe PMC] [Abstract]