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Chromosome 22 Open Reading Frame 28 (C22orf28)

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RTCB; tRNA-Splicing Ligase RtcB Homolog

Chromosome 22 Open Reading Frame 28 (C22orf28)
CCC W356
HGNC 26935
MGI 106379
PubMed 21490959
RGD 1303261
UniProt Q9Y3I0
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs. RtcB enzymes are novel RNA ligases that join 2’,3’-cyclic phosphate and 5’-OH ends. The phylogenetic distribution of RtcB points to its candidacy as a tRNA splicing/repair enzyme. Escherichia coli RtcB is competent and sufficient for tRNA splicing in vivo, by virtue of its ability to complement growth of yeast cells that lack the endogenous “healing/sealing-type” tRNA ligase Trl1. RtcB also protects yeast trl1Δ cells against a fungal ribotoxin that incises the anticodon loop of cellular tRNAs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW356Hu01 Recombinant Chromosome 22 Open Reading Frame 28 (C22orf28) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 22 Open Reading Frame 28 (C22orf28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 22 Open Reading Frame 28 (C22orf28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 22 Open Reading Frame 28 (C22orf28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 22 Open Reading Frame 28 (C22orf28) ELISA Kit Customized Service Offer
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  8. , Submitted (JUL-2007) to UniProtKB
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