Testis Specific Protein, Y-Linked 8 (TSPY8)

TSPY8 belongs to the nucleosome assembly protein (NAP) family.Nucleosome assembly proteins (NAPs) bind core histones, facilitate chromatin remodeling, and can act as transcriptional coactivators.

Its zygotic expression is restricted to neural cells, the outer cells of the ventral blood island (VBIs), and the ectoderm overlying the blood precursors.depletion of zygotic xNAP1L in embryos produces no obvious morphologic phenotype, but ablates -globin mRNA expression in the VBIs. Transcript levels of the hematopoietic precursor genes SCL and Xaml (Runx-1) are also reduced in the VBIs. Nucleosome assembly protein (NAP) family members are found in all eukaryotes, although primary sequence varies considerably among them, they share the ability to assemble nucleosomes in vitro.