Sp140 Like Protein (SP140L)

[Edit]

Nuclear body protein SP140-like protein

Sp140 Like Protein (SP140L)
SP140L Contains 1 HSR domain.Contains 1 PHD-type zinc finger.Contains 1 SAND domain.The N terminus of SP140, between amino acids 29 and 157, is 49% identical to a corresponding N-terminal region of SP100. The C terminus of SP140 contains a cysteine-rich zinc finger motif and a bromodomain. SP140 also has a central nuclear localization signal. RNA dot blot analysis detected high SP140 expression in spleen and peripheral blood leukocytes, with much lower levels in thymus, prostate, ovary, small intestine, and colon; other tissues showed little to no expression. Low expression of a smaller transcript was also observed. Western blot analysis with PBC autoantibodies detected SP140 at an apparent molecular mass of 140 kD following in vitro transcription and translation. Immunohistochemistry demonstrated that SP140 colocalized with PML in dense nuclear bodies in activated myeloid precursor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sp140 Like Protein (SP140L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sp140 Like Protein (SP140L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sp140 Like Protein (SP140L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sp140 Like Protein (SP140L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sp140 Like Protein (SP140L) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]