Translocase Of Inner Mitochondrial Membrane 23B (TIMM23B)

TIMM23B Belongs to the Tim17/Tim22/Tim23 family. May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex.

TIMM23 also has a 74-amino acid N-terminal hydrophilic segment that is dissimilar to the N-terminal hydrophilic domain of yeast Tim23. Northern blot analysis detected a 2.9-kb TIMM23 transcript that was highly expressed in heart and skeletal muscle, intermediately expressed in brain, and weakly expressed in pancreas, placenta, kidney, and liver. Western blot analysis showed that TIMM23 colocalizes with the inner membrane fraction of mitochondria as a 23-kD protein. TIMM23 is organized into 2 distinct 110-kD complexes in the inner membrane, one containing TIMM17A and the other containing TIMM17B.