![Unc-79 Homolog (UNC79)](/upload/item/img/Unc-79-Homolog-(UNC79)-89469.gif)
The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Lightweight (Lwt), disrupts the homolog of the Caenorhabditis elegans unc-79 gene. Experiments in C. elegans demonstrate a conserved hypersensitivity to ethanol in unc-79 mutants and extend this observation to the related unc-80 mutant and nca-1;nca-2 double mutants. Lightweight heterozygotes also exhibit an altered response to the anesthetic isoflurane, reminiscent of unc-79 invertebrate mutant phenotypes. The acute hypersensitivity to and increased voluntary consumption of ethanol observed in Lightweight heterozygous mice in combination with the observed hypersensitivity to ethanol in C. elegans unc-79, unc-80, and nca-1;nca-2 double mutants suggests a novel conserved pathway that might influence alcohol-related behaviors in humans.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Unc-79 Homolog (UNC79) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Unc-79 Homolog (UNC79) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Unc-79 Homolog (UNC79) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Unc-79 Homolog (UNC79) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Unc-79 Homolog (UNC79) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Unc-79 Homolog (UNC79) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Unc-79 Homolog (UNC79) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Unc-79 Homolog (UNC79) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Unc-79 Homolog (UNC79) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Unc-79 Homolog (UNC79) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Unc-79 Homolog (UNC79) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Unc-79 Homolog (UNC79) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Unc-79 Homolog (UNC79) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Unc-79 Homolog (UNC79) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Unc-79 Homolog (UNC79) | ELISA Kit Customized Service Offer |
- "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]