Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1)
[Edit]NPCR; NPCDRG; Nasopharyngeal Carcinoma-Related Gene Protein
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Both c-MYC knockdown and SPLUNC1 re-expression can down-regulate microRNA-141 (miR-141). miR-141 is up-regulated in NPC specimens in comparison with normal nasopharyngeal epithelium. Inhibition of miR-141 could affect cell cycle, apoptosis, cell growth, migration and invasion in NPC cells. BRD3, UBAP1 and PTEN are potential targets of miR-141, which had been confirmed following luciferase reporter assays and western blotting. BRD3 and UBAP1 are both involved in NPC carcinogenesis as confirmed and PTEN is a crucial tumor suppressor in many tumor types. BRD3 is involved in the regulation of the Rb/E2F pathway. Inhibition of miR-141 could affect some important molecules in the Rb/E2F, JNK2 and AKT pathways. It is well known that carcinogenesis of NPC is involved in the networks of genetic and epigenetic alteration events.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Nasopharyngeal Carcinoma Down Regulated Gene Protein 1 (NPCDR1) | ELISA Kit Customized Service Offer |