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GSK3 Beta Interaction Protein (GSKIP)

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C14orf129; Chromosome 14 Open Reading Frame 129

GSK3 Beta Interaction Protein (GSKIP)
CCC V208
HGNC 20343
MGI 1914037
PubMed 19830702
RGD 1308470
UniProt Q9P0R6
GSKIP, which binds to GSK3 beta. GSKIP is a good GSK3 beta substrate, and both the full-length protein and a C-terminal fragment of GSKIP can block phosphorylation of primed and nonprimed substrates in different fashions. Similar to Axin GID(381-405) and FRATtide, synthesized GSKIPtide is also shown to compete with and/or block the phosphorylation of Axin and beta-catenin by GSK3 beta. overexpression of GSKIP induces beta-catenin accumulation in the cytoplasm and nucleus as visualized by immunofluorescence. A functional assay also demonstrates that GSKIP-transfected cells have a significant effect on the transactivity of Tcf-4. GSKIP as a naturally occurring protein that is homologous with the GSK3 beta interaction domain of Axin and is able to negatively regulate GSK3 beta of the Wnt signaling pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GSK3 Beta Interaction Protein (GSKIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GSK3 Beta Interaction Protein (GSKIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GSK3 Beta Interaction Protein (GSKIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GSK3 Beta Interaction Protein (GSKIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GSK3 Beta Interaction Protein (GSKIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GSK3 Beta Interaction Protein (GSKIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GSK3 Beta Interaction Protein (GSKIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GSK3 Beta Interaction Protein (GSKIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GSK3 Beta Interaction Protein (GSKIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GSK3 Beta Interaction Protein (GSKIP) ELISA Kit Customized Service Offer
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta."Biochemistry 45:11379-11389(2006) [PubMed] [Europe PMC] [Abstract]
  6. "NMR structure of the human C14orf129 gene product, HSPC210. Northeast structural genomics target HR969."Submitted (JAN-2005) to the PDB data bank