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POC1 Centriolar Protein Homolog B (POC1B)

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WDR51B; Pix1; Proteome of centriole protein 1B; WD repeat-containing protein 51B

POC1 Centriolar Protein Homolog B (POC1B)
CCC V043
HGNC 30836
MGI 1918511
PubMed 23015594
UniProt Q8TC44
That cells depleted for both POC1A and POC1B show the absence of centrin-staining procentrioles, together with the localization of POC1 protein to procentrioles suggests that POC1 may be involved in an early stage of centriole assembly.
POC1 is recruited to nascent procentrioles and localizes in a highly asymmetrical pattern in mature centrioles corresponding to sites of basal-body fiber attachment. Knockdown of POC1 in human cells caused a reduction in centriole duplication, whereas overexpression caused the appearance of elongated centriole-like structures. Together, these data suggest that POC1 is involved in early steps of centriole duplication as well as in the later steps of centriole length control.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant POC1 Centriolar Protein Homolog B (POC1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to POC1 Centriolar Protein Homolog B (POC1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to POC1 Centriolar Protein Homolog B (POC1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for POC1 Centriolar Protein Homolog B (POC1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for POC1 Centriolar Protein Homolog B (POC1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant POC1 Centriolar Protein Homolog B (POC1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to POC1 Centriolar Protein Homolog B (POC1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to POC1 Centriolar Protein Homolog B (POC1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for POC1 Centriolar Protein Homolog B (POC1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for POC1 Centriolar Protein Homolog B (POC1B) ELISA Kit Customized Service Offer
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  4. "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells."Exp. Cell Res. 314:574-589(2008) [PubMed] [Europe PMC] [Abstract]
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  6. "Basal body stability and ciliogenesis requires the conserved component Poc1."J. Cell Biol. 187:905-920(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control."Mol. Biol. Cell 20:1150-1166(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Poc1A and Poc1B act together in human cells to ensure centriole integrity."J. Cell Sci. 126:163-175(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy." Am. J. Hum. Genet. 95:131-142(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Mutation of POC1B in a severe syndromic retinal ciliopathy." Hum. Mutat. 35:1153-1162(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Novel recessive cone-rod dystrophy caused by POC1B mutation."JAMA Ophthalmol. 132:1185-1191(2014) [PubMed] [Europe PMC] [Abstract]