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ROGDI is a novel gene which locates on human chromosome 16p13.3 and has unknown function. The length of ROGDI coding region is 864 bp which encodes 287 amino acids. CDK2 is a member of cyclin-dependent kinases (CDKs) which plays a key role in regulation of G1/S cell cycle transition and is activated during G1 and S phases. On the other hand, down-regulation of CDK2 and cyclin A was observed following silencing of ROGDI. In addition, the interaction between ROGDI and CDK2 was evidenced by using immunoprecipitation. ROGDI-enhanced cell proliferation was dependent on CDK2 activity. Flow cytometry profiles of depletion of ROGDI displayed G1/S phase arrest as well as up-reguated the expression of p53 and p21. ROGDI may be a positive regulator of cell cycle and its action is CDK2-depedent.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Rogdi Homolog (ROGDI) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Rogdi Homolog (ROGDI) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Rogdi Homolog (ROGDI) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Rogdi Homolog (ROGDI) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Rogdi Homolog (ROGDI) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Rogdi Homolog (ROGDI) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Rogdi Homolog (ROGDI) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Rogdi Homolog (ROGDI) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Rogdi Homolog (ROGDI) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Rogdi Homolog (ROGDI) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Rogdi Homolog (ROGDI) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Rogdi Homolog (ROGDI) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Rogdi Homolog (ROGDI) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Rogdi Homolog (ROGDI) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Rogdi Homolog (ROGDI) | ELISA Kit Customized Service Offer |
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