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DENN/MADD Domain Containing Protein 3 (DENND3)

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DENN/MADD Domain Containing Protein 3 (DENND3)
CCC U893
HGNC 29134
MGI 2146009
PubMed 24719330
RGD 1311559
UniProt A2RUS2
DENND3 Contains 1 dDENN domain.Contains 1 DENN domain.Contains 1 uDENN domain.Contains 3 WD repeats.
Rab6 regulates vesicular cargo at the level of Golgi via interactions with numerous and unrelated effector proteins. The crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 (Rab6 Interacting Protein 1) has been solved at 3.2Å resolution. This region of Rab6IP1 encompasses an all a -helical RUN domain followed in tandem by a PLAT domain that adopts a b -sandwich fold. The structure reveals that the first and last a -helices of the RUN domain mediate binding to switch I, switch II and the interswitch region of Rab6. The structure represents the largest Rab-effector complex determined to date.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 3 (DENND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 3 (DENND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 3 (DENND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 3 (DENND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 3 (DENND3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]