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DENN/MADD Domain Containing Protein 5B (DENND5B)

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Rab6IP1-Like Protein

DENN/MADD Domain Containing Protein 5B (DENND5B)
CCC U746
HGNC 28338
MGI 2444273
UniProt Q6ZUT9
DENND5B Belongs to the RAB6IP1 family.Contains 1 dDENN domain.Contains 1 DENN domain.Contains 1 PLAT domain.Contains 2 RUN domains.Contains 1 uDENN domain.
Rab6 regulates vesicular cargo at the level of Golgi via interactions with numerous and unrelated effector proteins. The crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 (Rab6 Interacting Protein 1) has been solved at 3.2Å resolution. This region of Rab6IP1 encompasses an all a -helical RUN domain followed in tandem by a PLAT domain that adopts a b -sandwich fold. The structure reveals that the first and last a -helices of the RUN domain mediate binding to switch I, switch II and the interswitch region of Rab6. The structure represents the largest Rab-effector complex determined to date.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 5B (DENND5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 5B (DENND5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 5B (DENND5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 5B (DENND5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 5B (DENND5B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 5B (DENND5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 5B (DENND5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 5B (DENND5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 5B (DENND5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 5B (DENND5B) ELISA Kit Customized Service Offer
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  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]