Hypoxia Inducible Domain Family, Member 1C (HIGD1C)

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Ubie; UbiE2

Hypoxia Inducible Domain Family, Member 1C (HIGD1C)
HIGD1C Contains 1 HIG1 domain. In efforts to identify important differences in gene expression in alpha vs. beta cells, a gene termed HIMP1 (HIG1) has been cloned from an alpha cell cDNA library. It is a member of a well conserved eukaryote protein family. In mice, its two alternatively spliced products each form a transmembrane loop, having an N(outside)-C(outside) orientation and are expressed highly in the mitochondrial inner membrane in several tissues including heart and pancreatic alpha cells, but not in beta cells.
Ectopic expression of HIMP1 in MIN6 beta cells protects the cells from apoptosis induced by several stimuli and prolongs their survival. These results suggest an important role for HIMP1 in stress protective programs in mitochondria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypoxia Inducible Domain Family, Member 1C (HIGD1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypoxia Inducible Domain Family, Member 1C (HIGD1C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxia Inducible Domain Family, Member 1C (HIGD1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypoxia Inducible Domain Family, Member 1C (HIGD1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypoxia Inducible Domain Family, Member 1C (HIGD1C) ELISA Kit Customized Service Offer
  1. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]