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Sesquipedalian 1 (Ses1)

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FAM109A; Family With Sequence Similarity 109, Member A; 27 kDa Inositol Polyphosphate Phosphatase-Interacting Protein A

Sesquipedalian 1 (Ses1)
CCC U483
HGNC 26509
MGI 2442708
UniProt Q8N4B1
Sesquipedalian 1 (Ses1) encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants.
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B.Was named after 'sesquipedalian', an unnecessarily long description of a simple thing. Early endosome. Recycling endosome. Golgi apparatus › trans-Golgi network. Cytoplasmic vesicle › clathrin-coated vesicle. Note: Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sesquipedalian 1 (Ses1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sesquipedalian 1 (Ses1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sesquipedalian 1 (Ses1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sesquipedalian 1 (Ses1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sesquipedalian 1 (Ses1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sesquipedalian 1 (Ses1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sesquipedalian 1 (Ses1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sesquipedalian 1 (Ses1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sesquipedalian 1 (Ses1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sesquipedalian 1 (Ses1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1."Proc. Natl. Acad. Sci. U.S.A. 107:3511-3516(2010) [PubMed] [Europe PMC] [Abstract]
  5. "The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway."Mol. Biol. Cell 22:606-623(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Recognition of the F&H motif by the Lowe syndrome protein OCRL."Nat. Struct. Mol. Biol. 18:789-795(2011) [PubMed] [Europe PMC] [Abstract]