t-SNARE Domain Containing Protein 1 (TSNARE1)

TSNARE1 Contains 1 t-SNARE coiled-coil homology domain.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE), VAMP-2 (v-SNARE), and the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.

The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a, which is required for neurotransmitter release, syntaxin 6, which is found in endosomal transport vesicles, yeast Sso1p, and Vam3p, a yeast syntaxin essential for vacuolar fusion. The SNARE motifs in these proteins share structural similarity, despite having a low level of sequence similarity.