RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4)

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RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4)
RPUSD4 Belongs to the pseudouridine synthase rluA family. RluA is a dual-specificity enzyme responsible for pseudouridylating 23S rRNA and several tRNAs. The 2.05 A resolution structure of RluA bound to a substrate RNA comprising the anticodon stem loop of tRNA(Phe) reveals that enzyme binding induces a dramatic reorganization of the RNA. Sequence conservation, the cocrystal structure, and the results of structure-guided mutagenesis suggest that RluA recognizes its substrates indirectly by probing RNA loops for their ability to adopt the reorganized fold. The planar, cationic side chain of an arginine intercalates between the reverse-Hoogsteen base pair and the bottom pair of the anticodon stem, flipping the nucleotide to be modified into the active site of RluA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Pseudouridylate Synthase Domain Containing Protein 4 (RPUSD4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]