WAP Four Disulfide Core Domain Protein 10B (WFDC10B)

[Edit]

WAP12

WAP Four Disulfide Core Domain Protein 10B (WFDC10B)
WFDC10B encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms.
In most cases, there is also a separate exon encompassing a few terminal codons and the 3' untranslated nucleotides. There are also examples of mixed type inhibitors, that encode inhibitor domains of both WAP and Kunitz types.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAP Four Disulfide Core Domain Protein 10B (WFDC10B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAP Four Disulfide Core Domain Protein 10B (WFDC10B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAP Four Disulfide Core Domain Protein 10B (WFDC10B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAP Four Disulfide Core Domain Protein 10B (WFDC10B) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAP Four Disulfide Core Domain Protein 10B (WFDC10B) ELISA Kit Customized Service Offer
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]