≡

Unkempt Homolog Like Protien (UNKL)

[Edit]

C16orf28; ZC3H5L; ZC3HDC5L; RING Finger Protein Unkempt-like; Zinc finger CCCH domain-containing protein 5-like; Putative E3 ubiquitin-protein ligase UNKL

Unkempt Homolog Like Protien (UNKL)
CCC T893
HGNC 14184
MGI 1921404
PubMed 1339381
UniProt Q9H9P5
Wiki UNKL
UNKL May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.Belongs to the unkempt family.
Contains 4 C3H1-type zinc fingers.Contains 1 RING-type zinc finger. Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with SMARCD2/BAF60b.Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven. Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unkempt Homolog Like Protien (UNKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unkempt Homolog Like Protien (UNKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unkempt Homolog Like Protien (UNKL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unkempt Homolog Like Protien (UNKL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unkempt Homolog Like Protien (UNKL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unkempt Homolog Like Protien (UNKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unkempt Homolog Like Protien (UNKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unkempt Homolog Like Protien (UNKL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unkempt Homolog Like Protien (UNKL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unkempt Homolog Like Protien (UNKL) ELISA Kit Customized Service Offer
  1. "The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt."FEBS J. 277:1453-1464(2010) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]