![RAB12, Member RAS Oncogene Family (RAB12)](/upload/item/img/RAB12--Member-RAS-Oncogene-Family-(RAB12)-87791.jpg)
A subfamily of small GTP-binding proteins, rab, has been shown to be involved in regulation of vesicular traffic in eukaryotic cells. The goal of this study was to identify the rab proteins associated with atrial secretory granules.
One of the small GTP-binding proteins associated with the atrial granules is a rab12 protein (rab12p), one of the rab proteins that are most closely related to a Sec4 protein of yeast. Association of rab12p with the atrial granules was confirmed by immunogold electron microscopy. Immunoprecipitation followed by immunoblot analysis with anti-rab12 antibody showed that in addition to atria, rab12p was expressed in multiple other organs and cell lines. These results suggest that rab12p may function in vesicular traffic in multiple diverse types of cells.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RAB12, Member RAS Oncogene Family (RAB12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RAB12, Member RAS Oncogene Family (RAB12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RAB12, Member RAS Oncogene Family (RAB12) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RAB12, Member RAS Oncogene Family (RAB12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RAB12, Member RAS Oncogene Family (RAB12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RAB12, Member RAS Oncogene Family (RAB12) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RAB12, Member RAS Oncogene Family (RAB12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RAB12, Member RAS Oncogene Family (RAB12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RAB12, Member RAS Oncogene Family (RAB12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RAB12, Member RAS Oncogene Family (RAB12) | ELISA Kit Customized Service Offer |
- "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterisation of novel Mss4-binding Rab GTPases."Biol. Chem. 392:239-248(2011) [PubMed] [Europe PMC] [Abstract]
- "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of a predicted human GTPase in complex with GDP."Submitted (FEB-2009) to the PDB data bank