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Dyslexia Susceptibility 2 Like Protein (DYLX2L)

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Dyslexia Associated Protein Like Protein

Dyslexia Susceptibility 2 Like Protein (DYLX2L)
CCC T767
HGNC 30071
MGI 2140475
UniProt Q8IZA0
DYLX2L is a candidate gene for dyslexia susceptibility. Contains a C6 region and PKD and MANSC domains at its N terminus and a transmembrane region at its C terminus. They identified 2 N-glycosylated KIAA0319L isoforms and a nonglycosylated isoform. Immunohistochemical analysis revealed that KIAA0319L colocalized with the axonal guidance protein NGR1 (RTN4R) in cytoplasmic granules, but not in nuclei, of human cortical neurons. Transfected HEK293 cells expressed a KIAA0319L protein at an apparent molecular mass of 140 kD. The transcript contains repetitive elements in its 3-prime end, and the deduced protein contains 639 amino acids. RT-PCR analysis revealed high KIAA0319L expression in adult amygdala and much lower expression in all adult and fetal tissues and specific adult brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dyslexia Susceptibility 2 Like Protein (DYLX2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dyslexia Susceptibility 2 Like Protein (DYLX2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dyslexia Susceptibility 2 Like Protein (DYLX2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dyslexia Susceptibility 2 Like Protein (DYLX2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dyslexia Susceptibility 2 Like Protein (DYLX2L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dyslexia Susceptibility 2 Like Protein (DYLX2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dyslexia Susceptibility 2 Like Protein (DYLX2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dyslexia Susceptibility 2 Like Protein (DYLX2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dyslexia Susceptibility 2 Like Protein (DYLX2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dyslexia Susceptibility 2 Like Protein (DYLX2L) ELISA Kit Customized Service Offer
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  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1."Cell. Mol. Neurobiol. 31:27-35(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the PKD domain from KIAA1837 protein."Submitted (OCT-2007) to the PDB data bank