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DENN/MADD Domain Containing Protein 4C (DENND4C)

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C9orf55B; C9orf55

DENN/MADD Domain Containing Protein 4C (DENND4C)
CCC T688
HGNC 26079
MGI 1914769
PubMed 21454697
UniProt Q5VZ89
DENND4C (DENN/MADD domain containing 4C), also known as DENN domain-containing protein 4C, C9orf55, C9orf55B, FLJ20686, bA513M16.3 or DKFZp686I09113, is a 1,673 amino acid multi-pass membrane protein.
DENND4C contains a dDENN domain, DENN domain, uDENN domain and a PPR (pentatricopeptide) repeat. As a result of alternative splicing, six DENND4C isoforms exist. The gene encoding DENND4C maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 4C (DENND4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 4C (DENND4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 4C (DENND4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 4C (DENND4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 4C (DENND4C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 4C (DENND4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 4C (DENND4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 4C (DENND4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 4C (DENND4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 4C (DENND4C) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]