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Cyclin N-Terminal Domain Containing Protein 2 (CNTD2)

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Cyclin N-Terminal Domain Containing Protein 2 (CNTD2)
CCC T679
HGNC 25805
UniProt Q9H8S5
Aurora-A is a mitotic kinase, which regulates cell cycle progression through modulating centrosome function. Aurora-A expression is frequently altered in human malignancies. CNTD2 as a novel Aurora-A partner and oncogene to activate Aurora-A and induce transformation. CNTD2 locates to chromosome 19q13.2 AKT2 amplicon. CNTD2 is amplified and overexpressed in human ovarian, pancreatic and lung cancer cell lines and primary tumors. CNTD2 colocalizes and interacts with Aurora-A in the centrosome. CNTD2 expression induces Aurora-A and cdc2 kinase activity, G2/M progression, and malignant transformation. These data indicate that CNTD2 is an oncogene and could play a pivotal role in Aurora-A activation during the cell cycle and that disruption of CNTD2-Aurora-A axis may represent a potential means to antitumor drug discovery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin N-Terminal Domain Containing Protein 2 (CNTD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin N-Terminal Domain Containing Protein 2 (CNTD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin N-Terminal Domain Containing Protein 2 (CNTD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin N-Terminal Domain Containing Protein 2 (CNTD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin N-Terminal Domain Containing Protein 2 (CNTD2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]