≡

Chromosome 17 Open Reading Frame 85 (C17orf85)

[Edit]

ELG Protein

Chromosome 17 Open Reading Frame 85 (C17orf85)
CCC T652
HGNC 24612
MGI 1914124
RGD 1308139
UniProt Q53F19
Role of Elg protein in double strand break repair. Elg1, which forms an alternative RFC-like complex with RFC2-5, is required for the maintenance of genome stability in Saccharomyces cerevisiae, and its function has been linked to DNA replication or damage checkpoint response. Elg1 is involved in homologous recombination (HR)-mediated DSB repair. Mutants of elg1 were partially defective in HR induced by methylmethanesufonate (MMS) and phleomycin. Deletion of ELG1 resulted in less efficient repair of phleomycin-induced DSBs in G2/M phase-arrested cells. During HR between MAT and HML loci, Elg1 associated with both the MAT locus near the HO endonuclease-induced DSB site, and the HML homologous donor locus. The association of Elg1 with the MAT locus was not dependent on Rad52. However, Elg1 association with the HML locus depended on Rad52.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 17 Open Reading Frame 85 (C17orf85) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 17 Open Reading Frame 85 (C17orf85) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 17 Open Reading Frame 85 (C17orf85) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 17 Open Reading Frame 85 (C17orf85) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 17 Open Reading Frame 85 (C17orf85) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]