Keratin Associated Protein 5-8 (KRTAP5-8)
[Edit]UHSKB; Ultrahigh sulfur keratin-associated protein 5.8
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is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Keratin Associated Protein 5-8 (KRTAP5-8) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Keratin Associated Protein 5-8 (KRTAP5-8) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Keratin Associated Protein 5-8 (KRTAP5-8) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Keratin Associated Protein 5-8 (KRTAP5-8) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Keratin Associated Protein 5-8 (KRTAP5-8) | ELISA Kit Customized Service Offer |
- "Genomic organization and promoter characterization of two human UHS keratin genes."Gene 227:137-148(1999) [PubMed] [Europe PMC] [Abstract]
- "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]