≡

Dyslexia Susceptibility Protein 2 (DYLX2)

[Edit]

DLX2; KIAA0319; DYX2; Dyslexia Associated Protein

Dyslexia Susceptibility Protein 2 (DYLX2)
CCC T590
HGNC 21580
MGI 3036268
RGD 1307443
UniProt Q5VV43
The KIAA0319 gene encodes a plasma membrane protein with a large, highly glycosylated, extracellular domain. This protein is proposed to function in adhesion and attachment and may play a role during neuronal migration in the developing brain. In addition, cleavage of the protein may play a role in intra- and extracellular signaling.The deduced 1,072-amino acid protein has an apparent molecular mass of over 100 kD by SDS-PAGE. RT-PCR detected low expression only in brain. The predicted size of the full-length protein is 116 kD. The transmembrane domain of the full-length KIAA0319 isoform was necessary for plasma membrane localization. The C6 domain was required for dimerization, and the transmembrane domain strengthened dimer interactions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dyslexia Susceptibility Protein 2 (DYLX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dyslexia Susceptibility Protein 2 (DYLX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dyslexia Susceptibility Protein 2 (DYLX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dyslexia Susceptibility Protein 2 (DYLX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dyslexia Susceptibility Protein 2 (DYLX2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A transcription map of the 6p22.3 reading disability locus identifying candidate genes."BMC Genomics 4:25-25(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration."Hum. Mol. Genet. 15:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Alternative splicing in the dyslexia-associated gene KIAA0319."Mamm. Genome 18:627-634(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms."Hum. Mol. Genet. 17:859-871(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway."Am. J. Physiol. 297:C160-C168(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat."Cereb. Cortex 20:884-897(2010) [PubMed] [Europe PMC] [Abstract]
  11. "The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage."J. Biol. Chem. 285:40148-40162(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the PKD domain (329-428) from human KIAA0319."Submitted (JUL-2007) to the PDB data bank
  13. "Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia."Am. J. Hum. Genet. 76:581-591(2005) [PubMed] [Europe PMC] [Abstract]