Wee1 Like Protein Kinase 2 (WEE2)

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WEE1B

Wee1 Like Protein Kinase 2 (WEE2)
WEE2 is a newly identified member of the WEE kinase family that is conserved from yeast to humans.Among 11 macaque tissues examined, WEE2 transcript is predominantly expressed in the ovary, only weakly detectable in the testis. Within the ovary, WEE2 mRNA is exclusively localized in the oocyte and appears to accumulate during folliculogenesis, reaching the highest level in preovulatory follicles. Microinjeciton of a full-length WEE2-GFP (green fluorescent protein) fusion mRNA indicates a specific nuclear localization of WEE2 protein in both growing and fully-grown germinal vesicle (GV)-intact oocytes. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cyclic Adenosine MonoPhosphate (cAMP) in nonhuman primates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase 2 (WEE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase 2 (WEE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase 2 (WEE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase 2 (WEE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase 2 (WEE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase 2 (WEE2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase 2 (WEE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase 2 (WEE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase 2 (WEE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase 2 (WEE2) ELISA Kit Customized Service Offer
  1. "Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases."Genes Cells 5:839-847(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]