Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H)

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ARHCL1; NERPP-2C; URCC2; Ras Homolog Gene Family, Member C Like 1; Neurite Extension-Related Protein Phosphatase Related to PP2C

Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H)
PPM1H possesses the potential to dephosphorylate p-nitrophenyl phosphate, casein and phosphopeptides.PPM1H shows the metal preference that is varied depending on the substrate; PPM1H prefers Mn(2+) when pNPP or phosphopeptides is used as a substrate. Meanwhile, a preference for Mg(2+) is displayed by PPM1H with casein as a substrate. When both cations are added to the reaction, the degree of the effect is always closer to that with Mn(2+) alone, irrespective of the substrate. This preponderance of Mn(2+) is explained by its greater affinity for PPM1H than Mg(2+). From the literature the substrate-dependent metal preference appears to be shared by other PP2Cs. According to the crystal structure, a binuclear metal center of PP2C plays an important role for coordinating the substrate and nucleophilic waters in the active site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) ELISA Kit Customized Service Offer
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  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "PPM1H is a p27 phosphatase implicated in trastuzumab resistance." Cancer Discov. 1:326-337(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]