SH3 Binding Domain Kinase 1 (SBK1)

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Sbk; Serine/threonine-protein kinase SBK1

SH3 Binding Domain Kinase 1 (SBK1)
SH3-binding domain kinase 1 (SBK1)is expressed in most of the cells and tissues examined, and the protein is highly up-regulated in ovarian serous adenocarcinoma while down-regulated in esophagus squamous cell carcinoma and stomach adenocarcinoma. When over-expressed in an ovarian cancer cells SK-OV-3 by adenovirus infection, SBK1 protected the cells from apoptosis induced by the viral infection, therefore promoting cancer cell survival. Given that a missense mutation K92E in human SBK1 was identified recently from ovarian mucinous carcinoma, together, these results suggest that the wide-spread expression pattern of human SBK1 may predict a broad cellular function, and its dysregulated in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Binding Domain Kinase 1 (SBK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Binding Domain Kinase 1 (SBK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Binding Domain Kinase 1 (SBK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Binding Domain Kinase 1 (SBK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Binding Domain Kinase 1 (SBK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Binding Domain Kinase 1 (SBK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Binding Domain Kinase 1 (SBK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Binding Domain Kinase 1 (SBK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Binding Domain Kinase 1 (SBK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Binding Domain Kinase 1 (SBK1) ELISA Kit Customized Service Offer
  1. "Cloning of human SBK1 cDNA and screening of its interaction proteins."Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 22:313-321(2006)
  2. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]