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Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B)

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C20orf77; CREPT; NET60; Cell cycle-related and expression-elevated protein in tumor

Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B)
CCC T374
HGNC 16209
MGI 1917720
PubMed 22231121
RGD 1304782
UniProt Q9NQG5
RPRD1B, Contains 1 CID domain. The beta-catenin inhibitory domain (CID) of APC located between the second and third 20 amino acid repeats and therefore present in many truncated APC products found in human tumours. In truncated APC, the CID is absolutely necessary to down-regulate the transcriptional activity and the level of beta-catenin, even when an axin/conductin binding site is present. The activity of the CID is dramatically reduced in several colon cancer cell lines and can be inhibited by shorter truncated APC lacking the CID.
The CID is a direct target of the selective pressure acting on APC during tumourigenesis. It explains the interdependence of both APC mutations, not only in colorectal but also in duodenal and desmoid tumours.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Polyclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulation Of Nuclear Pre-mRNA Domain Containing Protein 1B (RPRD1B) ELISA Kit Customized Service Offer
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