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N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1)

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PRED28; N6AMT; MTQ2; C21orf127; HEMK2; HemK Methyltransferase Family Member 2

N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1)
CCC T369
HGNC 16021
MGI 1915018
PubMed 21193388
RGD 1311843
UniProt Q9Y5N5
N6AMT1 belongs to the methyltransferase superfamily. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
N6AMT1 was able to convert MMAIII to the less toxic dimethylarsonic acid (DMA) when overexpressed in UROtsa cells. The enhanced expression of N6AMT1 in UROtsa cells decreased cytotoxicity of both iAsIII and MMAIII. Moreover, N6AMT1 is expressed in many human tissues at variable levels, although lower than those of AS3MT, supporting a potential participation in arsenic metabolism in vivo.N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity due to its specific activity in methylating MMAIII to DMA, and other unknown mechanisms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Polyclonal Antibody Customized Service Offer
Assay Kits SET369Hu ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1."FEBS Lett. 582:2352-2356(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity."Environ. Health Perspect. 119:771-777(2011) [PubMed] [Europe PMC] [Abstract]