CDK5 And Abl Enzyme Substrate 2 (CABLES2)

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C20orf150; ik3-2; Interactor with CDK3 2

CDK5 And Abl Enzyme Substrate 2 (CABLES2)
ik3-2 is a close relative to ik3-1/Cables, an associator with cdk3 and cdk5. ik3-1/Cables has been identified to be a candidate tumor suppressor for colon and head/neck cancers. ik3-1/Cables is a regulator for both p53- and p73-induced apoptosis although ectopic expression of ik3-1/Cables does not induce apoptosis. ik3-2 binds to p53 in vivo and ectopic coexpression of ik3-2 enhances apoptosis induced by adenovirus-mediated expression of p53. Furthermore, ectopic expression of ik3-2 results in apoptosis of primary p53/Mdm2- and p53/ARF-null mouse embryo fibroblasts, indicating that ik3-2-induced apoptosis is partially p53-independent. Both the highly conserved C-terminal cyclin box-homologous domain (ik3-2-C) and the N-terminal region consisting of 70 amino acids (ik3-2-N) are responsible for ik3-2-mediated enhancement of p53-induced apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 And Abl Enzyme Substrate 2 (CABLES2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 And Abl Enzyme Substrate 2 (CABLES2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 And Abl Enzyme Substrate 2 (CABLES2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 And Abl Enzyme Substrate 2 (CABLES2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 And Abl Enzyme Substrate 2 (CABLES2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]